ArticleCNS neuroscience & therapeutics2023
Orexinergic innervations at GABAergic neurons of the lateral habenula mediates the anesthetic potency of sevoflurane.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- State-dependent neuronal and network dynamics in the lateral hypothalamus across sevoflurane anesthesia-emergence revealed by microelectrode arrays.Microsystems & nanoengineering · 2026Article
- Deep Brain Stimulation of Lateral Habenula Ameliorates Depression-like Symptoms in Rats: Involvement of Mesolimbic Circuit.Neurochemical research · 2026Article
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- The Somatostatin Pathway Projected from the Basal Forebrain to the Lateral Habenula Promotes Isoflurane Anesthesia Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Basal Forebrain to Ventral Tegmental Area Glutamatergic Pathway Promotes Emergence from Isoflurane Anesthesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei.Neuroscience bulletin · 2024Review
- A hypothalamus-lateral periaqueductal gray GABAergic neural projection facilitates arousal following sevoflurane anesthesia in mice.CNS neuroscience & therapeutics · 2024Article
- Myelin modulates the process of isoflurane anesthesia through the regulation of neural activity.CNS neuroscience & therapeutics · 2024Article
- Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair.Translational psychiatry · 2024Article
- A Common Neuronal Ensemble in the Lateral Habenula Regulates Ciprofol Anesthesia in Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Recent advances in neural mechanism of general anesthesia induced unconsciousness: insights from optogenetics and chemogenetics.Frontiers in pharmacology · 2024Review
- Article
- Orexinergic innervations at GABAergic neurons of the lateral habenula mediates the anesthetic potency of sevoflurane.CNS neuroscience & therapeutics · 2023Article
- Mediation of lateral hypothalamus orexin input to lateral habenula in the inhibitory effects of mechanical stimulation on psychomotor responses induced by cocaine.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
- Erratum issuedErratum.2023
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe circuitry mechanism associated with anesthesia-induced unconsciousness is still largely unknown. It has been reported that orexinergic neurons of the lateral hypothalamus (LHA) facilitate the emergence from anesthesia through their neuronal projections to the arousal-promoting brain areas. However, the lateral habenula (LHb), as one of the orexin downstream targets, is known for its anesthesia-promoting effect. Therefore, the current study aimed to explore whether and how the orexinergic projections from the LHA to the LHb have a regulatory effect on unconsciousness induced by general anesthesia.
methodsWe applied optogenetic, chemogenetic, or pharmacological approaches to regulate the orexinergic
resultsWe found that activation of the orexinergic
conclusionThe orexinergic
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.