Evidence map›Paper›PMID 36740206›Full record

ArticleBiological psychiatry2023

Immersion Fixation and Staining of Multicubic Millimeter Volumes for Electron Microscopy-Based Connectomics of Human Brain Biopsies.

Neha Karlupia, Richard L Schalek, Yuelong Wu, Yaron Meirovitch, Donglai Wei, Alexander W Charney, Brian H Kopell, Jeff W Lichtman

Abstract read
In one paragraph

Article in Biological psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
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  9. Article
  10. Article
  11. Array tomography: trails to discovery.Methods in microscopy · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Connectomics of theeLife · 2023
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Neha KarlupiaDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts. Electronic address: nkarlupia@fas.harvard.edu.
Richard L SchalekDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts.
Yuelong WuDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts.
Yaron MeirovitchDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts.
Donglai WeiDepartment of Computer Science, Boston College, Boston, Massachusetts.
Alexander W CharneyIcahn School of Medicine, Mount Sinai, New York, New York.
Brian H KopellCenter for Neuromodulation, Department of Neurosurgery, The Icahn School of Medicine, Mount Sinai, New York, New York.
Jeff W LichtmanDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts. Electronic address: jeff@mcb.harvard.edu.

Funding

Zooming into the fish's brain-What is really going on! Connectomics analysis of larval zebrafish.U19NS104653 · NINDS · HARVARD UNIVERSITY · PI Jeff W Lichtman · 2017 to 2026
$39.4M
Res Support CoreP50MH094271 · NIMH · HARVARD UNIVERSITY · PI HENSCH, TAKAO K · 2011 to 2022
$18.6M
A multiscale investigation of the living human brainR01AG069976 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W · 2020 to 2024
$3.1M
A Tool for Synapse-level Circuit Analysis of Human Cerebral Cortex Specimens.UG3MH123386 · NIMH · HARVARD UNIVERSITY · PI LICHTMAN, JEFF W · 2021 to 2023
$2.4M
NIA NIH HHS R01 AG069976NIMH NIH HHS P50 MH094271NIMH NIH HHS UG3 MH123386NINDS NIH HHS U19 NS104653
6 · The paper itself

Abstract

Connectomics allows mapping of cells and their circuits at the nanometer scale in volumes of approximately 1 mm

Indexed as

ConnectomeBiopsyBrainHumansImmersionMicroscopy, ElectronStaining and LabelingBrain biopsyConnectomicsElectron microscopyHuman cortexImmersion fixationOsmium staining

Identifiers

PMID36740206
PMCPMC10397365

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.