Evidence map›Paper›PMID 36740192›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2023

Subphenotypes of frailty in lung transplant candidates.

Jonathan P Singer, Carolyn S Calfee, Kevin Delucchi, Joshua M Diamond, Michaela A Anderson, Luke A Benvenuto, Ying Gao, Ping Wang, Selim M Arcasoy, David J Lederer and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. The Path Forward: A Review on Enhanced Recovery After Cardiothoracic Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Jonathan P SingerDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA. Electronic address: jon.singer@ucsf.edu.
Carolyn S CalfeeDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Kevin DelucchiDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.
Joshua M DiamondDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Michaela A AndersonDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Luke A BenvenutoDivision of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York City, New York, USA.
Ying GaoDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Ping WangDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA; San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
Selim M ArcasoyDivision of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York City, New York, USA.
David J LedererRegeneron Pharmaceuticals, Tarrytown, New York, USA.
Steven R HaysDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Jasleen KukrejaDivision of Cardiothoracic Surgery, University of California, San Francisco, California, USA.
Aida VenadoDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Nicholas A KolaitisDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Lorianna E LeardDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Rupal J ShahDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Mary Ellen KleinhenzDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Jeffrey GoldenDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Legna BetancourtDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Michelle OysterDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Melanie BrownDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Derek ZaleskiDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nikhila MedikondaDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA.
Laurel KalmanDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Priya BalarDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Shreena PatelDivision of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York City, New York, USA.
Daniel R CalabreseDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA; San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
John R GreenlandDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, California, USA; San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
Jason D ChristieDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Long Term Follow up of the Lung Transplant Outcomes Group CohortU01HL145435 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D, PALMER, SCOTT M · 2019 to 2025
$10.2M
Frailty and patient centered outcomes in candidates for lung transplantationR01HL134851 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SINGER, JONATHAN PAUL · 2017 to 2021
$3.4M
The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation.U01HL163242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jonathan Paul Singer · 2022 to 2026
$2.8M
Telomere Dysfunction as a cause of Chronic Lung Allograft DysfunctionR01HL151552 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENLAND, JOHN · 2020 to 2024
$1.6M
Mentored Patient Oriented Research in Lung TransplantationK24HL115354 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2012 to 2021
$1.2M
The effects of lung transplantation on lung disease related disabilitiesF32HL107003 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SINGER, JONATHAN PAUL · 2011 to 2011
$63k
Cytomegalovirus Immune Responses in Chronic Lung Allograft Dysfunction PathogenesisI01CX002011 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI GREENLAND, JOHN · 2020 to 2025
–
BLRD VA IK2 BX005301CSRD VA I01 CX002011NHLBI NIH HHS F32 HL107003NHLBI NIH HHS K24 HL115354NHLBI NIH HHS R01 HL134851NHLBI NIH HHS R01 HL151552NHLBI NIH HHS U01 HL145435NHLBI NIH HHS U01 HL163242
6 · The paper itself

Abstract

Heterogeneous frailty pathobiology might explain the inconsistent associations observed between frailty and lung transplant outcomes. A Subphenotype analysis could refine frailty measurement. In a 3-center pilot cohort study, we measured frailty by the Short Physical Performance Battery, body composition, and serum biomarkers reflecting causes of frailty. We applied latent class modeling for these baseline data. Next, we tested class construct validity with disability, waitlist delisting/death, and early postoperative complications. Among 422 lung transplant candidates, 2 class model fit the best (P = .01). Compared with Subphenotype 1 (n = 333), Subphenotype 2 (n = 89) was characterized by systemic and innate inflammation (higher IL-6, CRP, PTX3, TNF-R1, and IL-1RA); mitochondrial stress (higher GDF-15 and FGF-21); sarcopenia; malnutrition; and lower hemoglobin and walk distance. Subphenotype 2 had a worse disability and higher risk of waitlist delisting or death (hazards ratio: 4.0; 95% confidence interval: 1.8-9.1). Of the total cohort, 257 underwent transplant (Subphenotype 1: 196; Subphenotype 2: 61). Subphenotype 2 had a higher need for take back to the operating room (48% vs 28%; P = .005) and longer posttransplant hospital length of stay (21 days [interquartile range: 14-33] vs 18 days [14-28]; P = .04). Subphenotype 2 trended toward fewer ventilator-free days, needing more postoperative extracorporeal membrane oxygenation and dialysis, and higher need for discharge to rehabilitation facilities (P ≤ .20). In this early phase study, we identified biological frailty Subphenotypes in lung transplant candidates. A hyperinflammatory, sarcopenic Subphenotype seems to be associated with worse clinical outcomes.

Indexed as

FrailtyLung TransplantationBiomarkersCohort StudiesHumansPilot ProjectsBiomarkersclinical research/practiceepidemiologylung transplantation/pulmonologypatient survivalrecipient selection

Identifiers

PMID36740192
PMCPMC11005295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.