Evidence map›Paper›PMID 36739916›Full record

ArticleJournal of neuroscience methods2023

Quantification of early gait development: Expanding the application of Catwalk technology to an infant rhesus macaque model.

Sabrina A Kabakov, Emma Crary, Viktorie Menna, Elaina R Razo, Jens C Eickhoff, Natalie R Dulaney, John R Drew, Kathryn M Bach, Aubreonna M Poole, Madison Stumpf and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sabrina A KabakovDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Emma CraryDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Viktorie MennaDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Elaina R RazoDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792.
Jens C EickhoffDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Natalie R DulaneyDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
John R DrewDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Kathryn M BachDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Aubreonna M PooleDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Madison StumpfDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Ann M MitzeyDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA; Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, 53715, USA; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Kerri B MalickiWisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, 53715, USA.
Michele L SchotzkoWisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, 53715, USA.
Kristen A PickettDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Nancy J Schultz-DarkenWisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, 53715, USA.
Marina E EmborgWisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, 53715, USA; Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
David H O'ConnorWisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, 53715, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Thaddeus G GolosDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA; Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, 53715, USA; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Emma L MohrDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792.
Karla K AusderauDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: kausderau@wisc.edu.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Zika virus pathophysiology during pregnancyP01AI132132 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$10.2M
Institutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7M
GBV-C-mediated protection from AIDS in humans and GBV-C/SIV co-infected macaquesR01AI116382 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2015 to 2018
$6.5M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
Early neural predictors and neuropathogenesis of sensorimotor neurodevelopmental deficits in macaque infants exposed to Zika virus in uteroR01AI153130 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI AUSDERAU, KARLA KAYE, MOHR, EMMA L · 2020 to 2024
$3.8M
Assessing the impact of acquired immunodeficiency on congenital Zika virusR01AI138647 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$3.8M
Defining maternal and neonatal antibody responses in congenital Zika virus infectionK08AI139341 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MOHR, EMMA L · 2019 to 2023
$1.0M
NCATS NIH HHS KL2 TR002374NCATS NIH HHS UL1 TR002373NIAID NIH HHS K08 AI139341NIAID NIH HHS P01 AI132132NIAID NIH HHS R01 AI116382NIAID NIH HHS R01 AI138647NIAID NIH HHS R01 AI153130NICHD NIH HHS U54 HD090256NIH HHS P51 OD011106
6 · The paper itself

Abstract

backgroundUnderstanding gait development is essential for identifying motor impairments in neurodevelopmental disorders. Defining typical gait development in a rhesus macaque model is critical prior to characterizing abnormal gait. The goal of this study was to 1) explore the feasibility of using the Noldus Catwalk to assess gait in infant rhesus macaques and 2) provide preliminary normative data of gait development during the first month of life. NEW

methodThe Noldus Catwalk was used to assess gait speed, dynamic and static paw measurements, and interlimb coordination in twelve infant rhesus macaques at 14, 21, and 28 days of age. All macaque runs were labeled as a diagonal or non-diagonal walking pattern.

resultsInfant rhesus macaques primarily used a diagonal (mature) walking pattern as early as 14 days of life. Ten infant rhesus macaques (83.3%) were able to successfully walk across the Noldus Catwalk at 28 days of life. Limited differences in gait parameters were observed between timepoints because of the variability within the group at 14, 21, and 28 days. COMPARISON WITH EXISTING

methodsNo prior gait analysis system has been used to provide objective quantification of gait parameters for infant macaques.

conclusionsThe Catwalk system can be utilized to quantify gait in infant rhesus macaques less than 28 days old. Future applications to infant rhesus macaques could provide a better understanding of gait development and early differences within various neurodevelopmental disorders.

Indexed as

GaitWalkingAnimalsMacaca mulattaCatwalkGaitInfantMotor developmentRhesus macaqueWalking pattern

Identifiers

PMID36739916
PMCPMC10191118

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.