ArticleBMC oral health2023
Factors for poor oral health in long-term childhood cancer survivors.
Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Dental management of long-term childhood cancer survivors: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Pooled it
- Long-term oral and dental effects in childhood acute lymphoblastic leukemia survivors: a cross-sectional study comparing early and late post-treatment periods.BMC oral health · 2026Article
- Awareness of oral health, hygiene practices, and chemotherapy-related oral manifestations among parents of pediatric oncology patients.BDJ open · 2026Article
- Dental caries in childhood cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Oral hygiene and cancer risk: emerging evidence and public health perspectives.Discover oncology · 2026Review
- Late Oral Complications in Childhood Cancer Survivors: Implications for Pediatric Dentistry and Survivorship Care.Children (Basel, Switzerland) · 2026Review
- Oral and Dental Sequelae After Oncological Treatment in Children: A Systematic Review.Journal of clinical medicine · 2025Review
- Virtual Reality as a Non-Pharmacological Aid for Reducing Anxiety in Pediatric Dental Procedures.Children (Basel, Switzerland) · 2025Article
- Article
- Dental Tissue Density in Healthy Children Based on Radiological Data: Retrospective Analysis.JMIRx med · 2024Article
- Late Complications in Long-Term Childhood Cancer Survivors: What the Oral Health Professional Needs to Know.Dentistry journal · 2024Review
- Xerostomia in patients with advanced cancer: a scoping review of clinical features and complications.BMC palliative care · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSurvivors of childhood cancer are at risk for therapy-related dental diseases. The purpose of the study was to investigate the associations between clinical, socioeconomic, and demographic factors and oral diseases in the St. Jude Lifetime Cohort (SJLIFE) participants.
methodsWe performed a retrospective medical chart review and evaluated longitudinal self-reported dental outcomes in 4856 childhood cancer survivors and 591 community controls participating in the St. Jude Lifetime Cohort (SJLIFE) study. Univariate and multivariable logistic regression models were used to assess the impact of socioeconomic factors, treatment exposures and patient demographics on dental outcomes.
resultsCancer survivors were more likely to report microdontia (odds ratio (OR) = 7.89, 95% confidence interval (CI) [4.64, 14.90]), abnormal root development (OR = 6.19, CI [3.38, 13.00]), hypodontia (OR = 2.75, CI [1.83, 4.33]), enamel hypoplasia (OR = 4.24, CI [2.9, 6.49]), xerostomia (OR = 7.72, CI [3.27, 25.10]), severe gingivitis (OR = 2.04, CI [1.43, 3.03]), and ≥ 6 missing teeth (OR = 3.73, CI [2.46, 6.00]) compared to controls without cancer history. Survivors who received classic alkylating agents (OR = 1.6, CI [1.36, 1.88]), anthracycline antibiotics (OR = 1.22, CI [1.04, 1.42] or radiation therapy potentially exposing the oral cavity (OR = 1.48, CI [1.26, 1.72]) were more likely to report at least one dental health problem after controlling for socioeconomic factors, age at last follow-up and diagnosis, other treatment exposures, and access to dental services. Survivors who had radiation therapy potentially exposing the oral cavity (OR = 1.52, CI [1.25, 1.84]) were also more likely to report at least one soft tissue abnormality after controlling for socioeconomic factors, age at last follow-up and diagnosis, other treatment exposures, and access and utilization of dental services.
conclusionsChildhood cancer survivors have a higher prevalence of oral-dental abnormalities than the controls without a cancer history. Cancer treatment, socioeconomic factors, and access to oral health care contribute to the prevalence of dental abnormalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.