Evidence map›Paper›PMID 36739344›Full record

SynthesisSports medicine - open2023

Effects and Optimal Dose of Exercise on Endothelial Function in Patients with Heart Failure: A Systematic Review and Meta-Analysis.

Laura Fuertes-Kenneally, Agustín Manresa-Rocamora, Carles Blasco-Peris, Fernando Ribeiro, Noemí Sempere-Ruiz, José Manuel Sarabia, Vicente Climent-Paya

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sports medicine - open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  12. Exercise snacks and physical fitness in sedentary populations.Sports medicine and health science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Laura Fuertes-KenneallyInstitute for Health and Biomedical Research of Alicante (ISABIAL), 03010, Alicante, Spain.ORCID http://orcid.org/0000-0003-1361-8806
Agustín Manresa-RocamoraInstitute for Health and Biomedical Research of Alicante (ISABIAL), 03010, Alicante, Spain. amanresa@umh.es.ORCID http://orcid.org/0000-0002-1399-2411
Carles Blasco-PerisInstitute for Health and Biomedical Research of Alicante (ISABIAL), 03010, Alicante, Spain.ORCID http://orcid.org/0000-0002-8257-1231
Fernando RibeiroInstitute of Biomedicine‑iBiMED and School of Health Sciences, University of Aveiro, 3810-193, Aveiro, Portugal.ORCID http://orcid.org/0000-0001-9094-1493
Noemí Sempere-RuizInstitute for Health and Biomedical Research of Alicante (ISABIAL), 03010, Alicante, Spain.ORCID http://orcid.org/0000-0002-1271-7194
José Manuel SarabiaInstitute for Health and Biomedical Research of Alicante (ISABIAL), 03010, Alicante, Spain.ORCID http://orcid.org/0000-0002-1917-6634
Vicente Climent-PayaInstitute for Health and Biomedical Research of Alicante (ISABIAL), 03010, Alicante, Spain.ORCID http://orcid.org/0000-0001-7362-1922
Universitat de Miguel Hernández d'Elx · ESHospital General Universitario de Alicante Doctor Balmis · ESUniversitat de València · ESUniversity of Aveiro · PT

Funding

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana 2021-0379
6 · The paper itself

Abstract

backgroundExercise-based cardiac rehabilitation (CR) is considered an effective treatment for enhancing endothelial function in patients with heart failure (HF). However, recent studies have been published and the optimal "dose" of exercise required to increase the benefits of exercise-based CR programmes on endothelial function is still unknown.

objectives(a) To estimate the effect of exercise-based CR on endothelial function, assessed by flow-mediated dilation (FMD), in patients with HF; (b) to determine whether high-intensity interval training (HIIT) is better than moderate-intensity training (MIT) for improving FMD; and (c) to investigate the influence of exercise modality (i.e. resistance exercise vs. aerobic exercise and combined exercise vs. aerobic exercise) on the improvement of endothelial function.

methodsElectronic searches were carried out in PubMed, Embase, and Scopus up to February 2022. Random-effects models of between-group mean differences were estimated. Heterogeneity analyses were performed by means of the chi-square test and I

resultsWe found a FMD increase of 3.09% (95% confidence interval [CI] = 2.01, 4.17) in favour of aerobic-based CR programmes compared with control groups in patients with HF and reduced ejection fraction (HFrEF). However, the results of included studies were inconsistent (p < .001; I

conclusionAerobic-based CR is a non-pharmacological treatment for enhancing endothelial function in patients with HFrEF. However, higher training frequency and HIIT induce greater adaptation of endothelial function in these patients, which should betaken into consideration when designing exercise-based CR programmes. Trial registration The protocol was prospectively registered on the PROSPERO database (CRD42022304687).

Indexed as

Aerobic exerciseEndothelial-dependent dilationExercise modalityFlow-mediated dilationHIITVascular smooth muscle function

Identifiers

PMID36739344
PMCPMC9899305
OpenAlexW4319170658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.