Evidence map›Paper›PMID 36739269›Full record

ArticleAdvanced healthcare materials2023

Design of Nanohydrogels for Targeted Intracellular Drug Transport to the Trans-Golgi Network.

Thorsten Keller, Nora Trinks, Jessica Brand, Steffen Trippmacher, Philipp Stahlhut, Krystyna Albrecht, Georg Papastavrou, Hermann Koepsell, Markus Sauer, Jürgen Groll

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Thorsten KellerDepartment for Functional Materials in Medicine and Dentistry, Institute of Functional Materials and Biofabrication, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.ORCID 0000-0002-2897-5761
Nora TrinksDepartment of Biotechnology and Biophysics, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Jessica BrandDepartment for Functional Materials in Medicine and Dentistry, Institute of Functional Materials and Biofabrication, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Steffen TrippmacherPhysical Chemistry II, University of Bayreuth, Universitätsstr. 30, 95440, Bayreuth, Germany.
Philipp StahlhutDepartment for Functional Materials in Medicine and Dentistry, Institute of Functional Materials and Biofabrication, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Krystyna AlbrechtDepartment for Functional Materials in Medicine and Dentistry, Institute of Functional Materials and Biofabrication, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Georg PapastavrouPhysical Chemistry II, University of Bayreuth, Universitätsstr. 30, 95440, Bayreuth, Germany.ORCID 0000-0002-5870-6693
Hermann KoepsellInstitute of Anatomy and Cell Biology, University of Würzburg, Koellikerstraße 6, 97070, Würzburg, Germany.ORCID 0000-0001-5118-7088
Markus SauerDepartment of Biotechnology and Biophysics, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.ORCID 0000-0002-1692-3219
Jürgen GrollDepartment for Functional Materials in Medicine and Dentistry, Institute of Functional Materials and Biofabrication, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.ORCID 0000-0003-3167-8466
University of Würzburg · DEUniversity of Bayreuth · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanohydrogels combine advantages of hydrogels and nanoparticles. In particular, they represent promising drug delivery systems. Nanogel synthesis by oxidative condensation of polyglycidol prepolymers, that are modified with thiol groups, results in crosslinking by disulfide bonds. Hereby, biomolecules like the antidiabetic peptide RS1-reg, derived from the regulatory protein RS1 of the Na

Indexed as

Monosaccharide Transport Proteinstrans-Golgi NetworkCaco-2 CellsHumansNanogelsPharmaceutical PreparationsPolyethylene GlycolsPolyethyleneiminePropylene GlycolsMonosaccharide Transport ProteinsNanogelsPharmaceutical Preparationspolyethylene glycol polyethyleneimine nanogelPolyethylene GlycolsPolyethyleneiminepolyglycidolPropylene Glycolsdrug deliverynanohydrogelsregulation of the Na+-D-glucose cotransporter SGLT1 in intestineregulatory protein RS1targeted transport

Identifiers

PMID36739269
PMCPMC11469190
OpenAlexW4319262228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.