ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2023
Family history, waist circumference and risk of ischemic stroke: A prospective cohort study among Chinese adults.
Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Family History and ASCVD Risk Among Different Age Groups: Cohort Study in China and the United Kingdom.JACC. Asia · 2026Article
- Joint effects of waist circumference trajectories and aging with risk of heart disease.BMC cardiovascular disorders · 2026Article
- The association of HIF1A gene polymorphism and its expression with ischemic stroke.Scientific reports · 2025Article
- Association between weight-adjusted waist index with incident stroke in the elderly with hypertension: a cohort study.Scientific reports · 2024Article
- The nonlinear relationship between triglyceride glucose-waist circumference and stroke risk in middle-aged and elderly people: a nationwide prospective cohort study of the CHARLS.Lipids in health and disease · 2024Observational
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsThe associations between genetic factors and waist circumference (WC) with stroke risk have been evaluated in Western studies. However, evidence of this association has rarely been reported in the Chinese population. This study aimed to evaluate the association between WC and family history of stroke (FHS) with ischemic stroke (IS) risk among Chinese adults and to further explore the potential interaction of these associations. METHODS AND
resultsThe China Kadoorie Biobank (CKB) study recruited 35,508 participants aged 30-79 years from the Qingdao urban area during 2004-2008. A total of 33,355 participants were included in study. Cox regression analysis was used to estimate the multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the independent and interactional associations between FHS and WC and IS risk. Participants with FHS had a 29% (HR = 1.29, 95% CI: 1.12-1.50) higher IS risk than those without FHS. Participants with excessive WC (85 cm for males and 80 cm for females) had a 78% (HR = 1.78, 95% CI: 1.51-2.10) higher IS risk than those with normal WC. The combined effect of FHS and excessive WC on IS was statistically significant (HR = 2.29, 95% CI: 1.84-2.86). The present study further found statistically significant multiplicative interactions of FHS and WC with IS risk (P
conclusionThe present study indicated that FHS and WC were significantly associated with an increased risk of IS. The association between FHS and IS was associated with excessive WC.
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