ArticleAngewandte Chemie (International ed. in English)2023
Deuterodehalogenation Under Net Reductive or Redox-Neutral Conditions Enabled by Paired Electrolysis.
Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Electrochemically deuterated silane synthesis with DScience advances · 2026Article
- Electricity-driven site-selective deuteration of pharmaceuticals.Chemical science · 2026Article
- Transition-metal-free electrochemical cross-electrophile coupling of activated benzyl alcohols and primary alkyl bromides.Science advances · 2026Article
- Mechanochemical Dehalogenative Deuteration of Alkyl Halides Through Piezoelectric Catalysis Initiated by a Single-Electron Oxidation Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Electrochemical cobalt-catalyzed semi-deuteration of alkynes to access deuterated Z-alkenes.Nature communications · 2025Article
- Hydro- and deutero-deamination of primary amines using O-diphenylphosphinylhydroxylamine.Nature communications · 2024Article
- Ni-Catalyzed Asymmetric Reductive Arylation of α-Substituted Imides.Journal of the American Chemical Society · 2024Article
- Electrochemical Glycosylation via Halogen-Atom-Transfer forACS catalysis · 2024Article
- Electroreductive deuteroarylation of alkenes enabled by an organo-mediator.Chemical science · 2024Article
- Electrochemical Late-Stage Functionalization.Chemical reviews · 2023Review
- Deep Electroreductive Chemistry: Harnessing Carbon- and Silicon-based Reactive Intermediates in Organic Synthesis.ACS catalysis · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Interest in deuterated active pharmaceutical ingredients (APIs) is increasing as deuteration holds promise for kinetic isotope effect (KIE) regulated fine-tuning of API performance. Moreover, deuterium isotope labeling is frequently carried out to study organic and bioorganic reaction mechanisms and to facilitate complex target synthesis. As such, methods for highly selective deuteration of organic molecules are highly desirable. Herein, we present an electrochemical method for the selective deuterodehalogenation of benzylic halides via a radical-polar crossover mechanism, using inexpensive deuterium oxide (D
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Registered trials
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