Evidence map›Paper›PMID 36738427›Full record

ArticleFrontiers of medicine2023

NETO2 promotes melanoma progression via activation of the Ca

Susi Zhu, Xu Zhang, Yeye Guo, Ling Tang, Zhe Zhou, Xiang Chen, Cong Peng

Abstract read
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In one paragraph

Article in Frontiers of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Susi ZhuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 41000, China.
Xu ZhangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 41000, China.
Yeye GuoDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 41000, China.
Ling TangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 41000, China.
Zhe ZhouDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 41000, China.
Xiang ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 41000, China. chenxiangck@126.com.
Cong PengDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, 41000, China. pengcongxy@csu.edu.cn.
Central South University · CNNational Clinical Research · USSKiN Health · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is the most aggressive cutaneous tumor. Neuropilin and tolloid-like 2 (NETO2) is closely related to tumorigenesis. However, the functional significance of NETO2 in melanoma progression remains unclear. Herein, we found that NETO2 expression was augmented in melanoma clinical tissues and associated with poor prognosis in melanoma patients. Disrupting NETO2 expression markedly inhibited melanoma proliferation, malignant growth, migration, and invasion by downregulating the levels of calcium ions (Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2MelanomaBenzenesulfonamidesBenzylaminesCell Line, TumorCell ProliferationHumansMembrane ProteinsPhosphorylationSignal TransductionBenzenesulfonamidesBenzylaminesCalcium-Calmodulin-Dependent Protein Kinase Type 2KN 93Membrane ProteinsNETO2 protein, humanCa2+/CaMKII signaling pathwaymelanomaneuropilin and tolloid-like 2

Identifiers

PMID36738427
OpenAlexW4319071946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.