Evidence map›Paper›PMID 36738370›Full record

ReviewAdvances in therapy2023

Aminoglycoside-Related Nephrotoxicity and Ototoxicity in Clinical Practice: A Review of Pathophysiological Mechanism and Treatment Options.

Tyler A Le, Tasneem Hiba, Disha Chaudhari, Arielle N Preston, Zachary R Palowsky, Shahab Ahmadzadeh, Sahar Shekoohi, Elyse M Cornett, Alan D Kaye

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Biology · 2026
    Article
  3. Review
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  6. Article
  7. Article
  8. Review
  9. Article
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  16. Antimicrobial Resistance Phenotypes and Genotypes ofAntibiotics (Basel, Switzerland) · 2025
    Article
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  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Tyler A LeAmerican University of the Caribbean, 1 University Drive at, Jordan Dr, Cupecoy, Sint Maarten.
Tasneem HibaAmerican University of the Caribbean, 1 University Drive at, Jordan Dr, Cupecoy, Sint Maarten.
Disha ChaudhariAmerican University of the Caribbean, 1 University Drive at, Jordan Dr, Cupecoy, Sint Maarten.
Arielle N PrestonAmerican University of the Caribbean, 1 University Drive at, Jordan Dr, Cupecoy, Sint Maarten.
Zachary R PalowskyDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Shahab AhmadzadehDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Elyse M CornettDepartment of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA. sahar.shekoohi@lsuhs.edu.ORCID http://orcid.org/0000-0001-7961-3931
Alan D KayeLouisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Louisiana State University Health Sciences Center Shreveport · USAmerican University of the Caribbean School of Medicine · SX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aminoglycosides are a class of medications used to treat certain bacterial infections, specifically gram-negative aerobes. These drugs can be used alone as first-line treatments or in combination with other medications. There can be many different formulations of aminoglycosides including oral, inhalants, intravascular, intramuscular, or intraventricular. There are many distinctive types of aminoglycosides, and although they provide excellent coverage, they can have a wide variety of side effects. The most prevalent side effects of aminoglycosides are nephrotoxicity and ototoxicity. Aminoglycoside-induced nephrotoxicity is concerning because of the effects that abnormal creatinine levels can have on other drugs and the potential for neurotoxicity. Fortunately, changes in renal function are typically reversible. The kidney is affected by the drug's ability to enter the proximal tubule and cause a buildup of phospholipids in the lysosomes, inhibiting their function. Exposure to aminoglycosides in utero can result in permanent ototoxicity. The mechanism of ototoxicity is through the drug's ability to freely pass into hair cells and cause reactive oxygen species to damage the mitochondria, resulting in cell death. There is not a substantial amount of research regarding the prevention and treatment of adverse effects of aminoglycosides. Future research on the mediation or modulation of these pathophysiological processes would expand their usage in modern medicine.

Indexed as

Bacterial InfectionsDrug-Related Side Effects and Adverse ReactionsOtotoxicityAminoglycosidesAnti-Bacterial AgentsHumansKidneyAminoglycosidesAnti-Bacterial AgentsAminoglycosidesAntibioticsNephrotoxicityOtotoxicity

Identifiers

PMID36738370
OpenAlexW4319216341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.