Evidence map›Paper›PMID 36738307›Full record

ArticleEuropean journal of preventive cardiology2023

Vascular ageing: moving from bench towards bedside.

Rachel E Climie, Jordi Alastruey, Christopher C Mayer, Achim Schwarz, Agne Laucyte-Cibulskiene, Julija Voicehovska, Elisabetta Bianchini, Rosa-Maria Bruno, Peter H Charlton, Andrea Grillo and 14 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in European journal of preventive cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
25.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Pathophysiology and Clinical Relevance of Microvascular Remodeling in Arterial Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Vascular Age: A narrative review of assessment methods, clinical applications, and future directions.International journal of cardiology. Cardiovascular risk and prevention · 2026
    Review
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Impact of vascular aging on stroke prognosis: the novel severity and arterial stiffness (SASt) score.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 20 institutions in 16 countries.

Rachel E ClimieMenzies Institute for Medical Research, University of Tasmania, 17 Liverpool St, 7000 Hobart, Australia.ORCID 0000-0002-7960-360X
Jordi AlastrueyDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, 249 Westminster Bridge Rd, London SE1 7EH, UK.
Christopher C MayerMedical Signal Analysis, Center for Health & Bioresources, AIT Austrian Institute of Technology, Giefinggasse 4, 1210 Vienna, Austria.ORCID 0000-0002-5612-5481
Achim SchwarzALF Distribution GmbH, Stephanstrasse 19, 52064 Aachen, Germany.
Agne Laucyte-CibulskieneDepartment of Clinical Sciences, Lund University, Skane University Hospital, Sölvegatan 19 - BMC F12, 221 84 Lund, Malmö, Sweden.
Julija VoicehovskaDepartment of Internal Diseases, Riga Stradins University, Dzirciema str. 16, Riga, L-1007, Latvia.
Elisabetta BianchiniInstitute of Clinical Physiology, Italian National Research Council (CNR), Via Moruzzi, 1, 56124 Pisa (PI), Italy.
Rosa-Maria BrunoIntegrative Epidemiology of Cardiovascular Disease, Université de Paris, INSERM, U970, Paris Cardiovascular Research Center (PARCC), 56 rue Leblanc, 75015 Paris, France.
Peter H CharltonDepartment of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, 2 Worts Causeway, Cambridge CB1 8RN, UK.ORCID 0000-0003-3836-8655
Andrea GrilloMedicina Clinica, Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy.
Andrea GualaVall d'Hebron Institut de Recerca (VHIR), Paseo de la Vall d'Hebron, 129, 08035 Barcelona, Spain.
Magid HallabClinique Bizet, 23 Georges Bizet, 75116 Paris, France.
Bernhard HametnerMedical Signal Analysis, Center for Health & Bioresources, AIT Austrian Institute of Technology, Giefinggasse 4, 1210 Vienna, Austria.ORCID 0000-0003-2048-1019
Piotr JankowskiDepartment of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 231 Czerniakowska St., 00-416 Warsaw, Poland.
Karsten KönigsteinDepartment of Sport, Exercise and Health (DSBG) University of Basel, Grosse Allee 6, 4052 Basel, Switzerland.
Anna LebedevaDepartment of Internal Medicine and Cardiology, Dresden Heart Centre, Dresden University of Technology, Fetscher str. 76, 01307 Dresden, Germany.
Ioana MozosDepartment of Functional Sciences-Pathophysiology, Center for Translational Research and Systems Medicine, 'Victor Babes' University of Medicine and Pharmacy, T. Vladimirescu Street 14, 300173 Timisoara, Romania.
Giacomo PucciUnit of Internal Medicine, Terni University Hospital - Department of Medicine and Surgery, University of Perugia, Terni, Italy.
Houry PuzantianHariri School of Nursing, American University of Beirut, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon.
Dimitrios Terentes-PrintziosFirst Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias Avenue, 11527 Athens, Greece.ORCID 0000-0003-4039-8263
Gunay Yetik-AnacakDepartment of Pharmacology, Faculty of Pharmacy, Acibadem Mehmet Ali Aydinlar University, Kayisdagi Cad. No:32 Atasehir, 34752 Istanbul, Turkey.
Chloe ParkMRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London WC1E 7HB, UK.
Peter M NilssonDepartment of Clinical Sciences, Lund University, Skane University Hospital, Sölvegatan 19 - BMC F12, 221 84 Lund, Malmö, Sweden.
Thomas WeberCardiology Department, Klinikum Wels-Grieskirchen, Grieskirchnerstrasse 42, 4600 Wels, Austria.
Austrian Institute of Technology · ATAmerican University of Beirut · LBInserm · FRIstituto di Fisiologia Clinica · ITKent Hastanesi · TRKing's College London · GBKlinikum Wels-Grieskirchen · ATLund University · SEMRC Unit for Lifelong Health and Ageing · GBNational and Kapodistrian University of Athens · GRPostgraduate School of Molecular Medicine · PLRiga East University Hospital · LVTechnische Universität Dresden · DEUniversity of Basel · CHUniversity of Cambridge · GBUniversity of Perugia · ITUniversity of Tasmania · AUUniversity of Trieste · ITVall d'Hebron Institut de Recerca · ESVictor Babeș University of Medicine and Pharmacy Timișoara · RO

Funding

British Heart Foundation PG/15/104/31913Department of Health MIC-2016-019Wellcome Trust 105636
6 · The paper itself

Abstract

Prevention of cardiovascular disease (CVD) remains one of the largest public health challenges of our time. Identifying individuals at increased cardiovascular risk at an asymptomatic, sub-clinical stage is of paramount importance for minimizing disease progression as well as the substantial health and economic burden associated with overt CVD. Vascular ageing (VA) involves the deterioration in vascular structure and function over time and ultimately leads to damage in the heart, brain, kidney, and other organs. Vascular ageing encompasses the cumulative effect of all cardiovascular risk factors on the arterial wall over the life course and thus may help identify those at elevated cardiovascular risk, early in disease development. Although the concept of VA is gaining interest clinically, it is seldom measured in routine clinical practice due to lack of consensus on how to characterize VA as physiological vs. pathological and various practical issues. In this state-of-the-art review and as a network of scientists, clinicians, engineers, and industry partners with expertise in VA, we address six questions related to VA in an attempt to increase knowledge among the broader medical community and move the routine measurement of VA a little closer from bench towards bedside.

Indexed as

Cardiovascular DiseasesAgingArteriesHumansAgeingCardiovascular disease preventionVascular damage

Identifiers

PMID36738307
PMCPMC7614971
OpenAlexW4319216374

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.