ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Neural Mechanisms of Age-Related Loss of Muscle Performance and Physical Function.
Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice.Aging cell · 2026Article
- Dual-Tasking Exacerbates Force and Neural Control Unsteadiness in Older Adults With Sarcopenia.Journal of cachexia, sarcopenia and muscle · 2026Article
- Article
- Electrical bioimpedance spectral markers distinguish balance ability in older adults without provoking fall risk.Journal of neuroengineering and rehabilitation · 2026Article
- Skeletal Muscle Function Deficit Longitudinal Associations With Inflammation and Caloric Intake in Elderly. The InCHIANTI Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Influence of sarcopenia on functional independence and depression in older adults: a cross-sectional study.Journal of exercise rehabilitation · 2026Article
- Daily activity patterns from wearable accelerometry predict physical frailty and concern about falling.NPJ digital medicine · 2026Article
- Interplay between sarcopenia and type 2 diabetes: mechanisms, implications, and therapeutic prospects.Nutrition & diabetes · 2026Review
- Exercise, exerkines, and muscle-brain crosstalk in Parkinson's disease.Neuroprotection (Chichester, England) · 2026Review
- Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults.The Journal of physiology · 2026Article
- Tongue blade neuromuscular junction defects in old F344 rats.Respiratory physiology & neurobiology · 2026Article
- Identifying Individuals at Risk of Functional Decline Despite Preserved Muscle Mass: Insights from Appendicular Skeletal Muscle Mass and Handgrip Strength Discordance.Journal of clinical medicine · 2026Article
- Resistance training effects on gait parameters in older adults-a systematic review with multilevel meta-analysis and meta-regression.GeroScience · 2026Review
- Striatal dopamine and skeletal muscle energy metabolism in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The association between handgrip strength, physical, and cognitive function among hospitalized older adults in Tanzania.BMC geriatrics · 2026Article
- Association between neurofilament light chain, glial fibrillary acidic protein, and sarcopenia in older Indian adults: evidence from LASI-DAD.BMC geriatrics · 2026Article
- Grip strength-to-weight ratio, all-cause and cardiovascular mortality, and cardiovascular disease prevalence: Evidence from NHANES and CHARLS.American journal of preventive cardiology · 2026Article
- Tensiomyography-derived contractile parameters in sarcopenic and non-sarcopenic older adults.Frontiers in aging · 2026Article
- Muscle-brain crosstalk in sarcopenia and cognitive impairment: endocrine signaling, metabolic regulation, and exercise modulation.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundThis article discusses the putative neural mechanisms of age-related muscle weakness within the broader context of the development of function-promoting therapies for sarcopenia and age-related mobility limitations. We discuss here the evolving definition of sarcopenia and its primary defining characteristic, weakness.
methodsThis review explores the premise that impairments in the nervous system's ability to generate maximal force or power contribute to sarcopenia.
resultsImpairments in neural activation are responsible for a substantial amount of age-related weakness. The neurophysiological mechanisms of weakness are multifactorial. The roles of supraspinal descending command mechanisms, spinal motor neuron firing responsivity, and neuromuscular junction transmission failure in sarcopenia are discussed. Research/clinical gaps and recommendations for future work are highlighted.
conclusionFurther research is needed to map putative neural mechanisms, determine the clinical relevance of age-related changes in neural activation to sarcopenia, and evaluate the effectiveness of various neurotherapeutic approaches to enhancing physical function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.