Evidence map›Paper›PMID 36737843›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Mobile and Self-Sustained Data Storage in an Extremophile Genomic DNA.

Fajia Sun, Yiming Dong, Ming Ni, Zhi Ping, Yuhui Sun, Qi Ouyang, Long Qian

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Highly Secure In Vivo DNA Data Storage Driven by Genomic Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. DNA storage: The future direction for medical cold data storage.Synthetic and systems biotechnology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. "Cell Disk" DNA Storage System Capable of Random Reading and Rewriting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  11. Article
  12. Article
  13. Mobile and Self-Sustained Data Storage in an Extremophile Genomic DNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fajia SunCenter for Quantitative Biology, Peking University, 5 Yiheyuan Road Haidian District, Beijing, 100871, P. R. China.ORCID 0000-0001-6972-8161
Yiming DongCenter for Quantitative Biology, Peking University, 5 Yiheyuan Road Haidian District, Beijing, 100871, P. R. China.
Ming NiAcademician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Huada Comprehensive Park, Yantian District, Shenzhen, 518083, P. R. China.
Zhi PingAcademician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Huada Comprehensive Park, Yantian District, Shenzhen, 518083, P. R. China.
Yuhui SunAcademician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Huada Comprehensive Park, Yantian District, Shenzhen, 518083, P. R. China.
Qi OuyangCenter for Quantitative Biology, Peking University, 5 Yiheyuan Road Haidian District, Beijing, 100871, P. R. China.
Long QianCenter for Quantitative Biology, Peking University, 5 Yiheyuan Road Haidian District, Beijing, 100871, P. R. China.ORCID 0000-0003-3728-7917
Peking University · CNBGI Group (China) · CN

Funding

National Key R&D Program of China 2020YFA0906900National Key R&D Program of China 2021YFF1200100National Key R&D Program of China 2021YFF1200500National Natural Science Foundation of China 12090054National Natural Science Foundation of China 31901063
6 · The paper itself

Abstract

DNA has been pursued as a novel biomaterial for digital data storage. While large-scale data storage and random access have been achieved in DNA oligonucleotide pools, repeated data accessing requires constant data replenishment, and these implementations are confined in professional facilities. Here, a mobile data storage system in the genome of the extremophile Halomonas bluephagenesis, which enables dual-mode storage, dynamic data maintenance, rapid readout, and robust recovery. The system relies on two key components: A versatile genetic toolbox for the integration of 10-100 kb scale synthetic DNA into H. bluephagenesis genome and an efficient error correction coding scheme targeting noisy nanopore sequencing reads. The storage and repeated retrieval of 5 KB data under non-laboratory conditions are demonstrated. The work highlights the potential of DNA data storage in domestic and field scenarios, and expands its application domain from archival data to frequently accessed data.

Indexed as

ExtremophilesDNAGenomicsInformation Storage and RetrievalSequence Analysis, DNADNAbiomaterialsDNA data storageerror correction codesgenome engineeringnanopore sequencing

Identifiers

PMID36737843
PMCPMC10074078
OpenAlexW4319216030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.