Evidence map›Paper›PMID 36737833›Full record

ArticleBiomaterials research2023

White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment.

Qinchao Zhu, Xuhao Zhou, Yanan Zhang, Di Ye, Kang Yu, Wangbei Cao, Liwen Zhang, Houwei Zheng, Ziyang Sun, Chengchen Guo and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Qinchao Zhu *Institute of Dairy Science, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China.
Xuhao Zhou *Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, School of Medicine, Zhejiang University, 310027, Hangzhou, China.
Yanan ZhangKey Laboratory of Animal Virology of Ministry of Agriculture, Center for Veterinary Sciences, Zhejiang University, 310058, Hangzhou, China.
Di YeDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China.
Kang YuKey Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, 310027, Hangzhou, China.
Wangbei CaoMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China.
Liwen ZhangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China.
Houwei ZhengMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China.
Ziyang SunSchool of Engineering, Westlake University, 310023, Hangzhou, Zhejiang, China.
Chengchen GuoSchool of Engineering, Westlake University, 310023, Hangzhou, Zhejiang, China.
Xiaoqian HongDepartment of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, School of Medicine, Zhejiang University, 310027, Hangzhou, China.
Yang ZhuMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China.
Yajun ZhangSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310020, Hangzhou, Zhejiang, China.
Ying XiaoSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310020, Hangzhou, Zhejiang, China.
Teresa G ValencakInstitute of Dairy Science, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China.
Tanchen RenDepartment of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, School of Medicine, Zhejiang University, 310027, Hangzhou, China. rentanchen120@zju.edu.cn.
Daxi RenInstitute of Dairy Science, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China. dxren@zju.edu.cn.ORCID http://orcid.org/0000-0002-8016-0033
Zhejiang University · CNSecond Affiliated Hospital of Zhejiang University · CNSir Run Run Shaw Hospital · CNWestlake University · CN

Funding

Guangxi Key Research and Development Program AB1850017National Key Research and Development Program of China 2021YFA1101100National Natural Science Foundation of China 32000971
6 · The paper itself

Abstract

backgroundPost-traumatic massive hemorrhage demands immediately available first-aid supplies with reduced operation time and good surgical compliance. In-situ crosslinking gels that are flexibly adapting to the wound shape have a promising potential, but it is still hard to achieve fast gelation, on-demand adhesion, and wide feasibility at the same time.

methodsA white-light crosslinkable natural milk-derived casein hydrogel bioadhesive is presented for the first time. Benefiting from abundant tyrosine residues, casein hydrogel bioadhesive was synthesized by forming di-tyrosine bonds under white light with a ruthenium-based catalyst. We firstly optimized the concentration of proteins and initiators to achieve faster gelation and higher mechanical strength. Then, we examined the degradation, cytotoxicity, tissue adhesion, hemostasis, and wound healing ability of the casein hydrogels to study their potential to be used as bioadhesives.

resultRapid gelation of casein hydrogel is initiated with an outdoor flashlight, a cellphone flashlight, or an endoscopy lamp, which facilitates its usage during first-aid and minimally invasive operations. The rapid gelation enables 3D printing of the casein hydrogel and excellent hemostasis even during liver hemorrhage due to section injury. The covalent binding between casein and tissue enables robust adhesion which can withstand more than 180 mmHg blood pressure. Moreover, the casein-based hydrogel can facilitate post-traumatic wound healing caused by trauma due to its biocompatibility.

conclusionCasein-based bioadhesives developed in this study pave a way for broad and practical application in emergency wound management.

Indexed as

BioadhesiveCaseinHemostasisphotocrosslinkWound healing

Identifiers

PMID36737833
PMCPMC9898936
OpenAlexW4319073910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.