SynthesisJournal of orthopaedic surgery and research2023
Vacuum-assisted closure versus conventional dressing in necrotizing fasciitis: a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05883033 (Comparative Study Between Vacuum Assisted Closure), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Study Between Vacuum Assisted Closure (VAC) and Conventional Dressing in the Healing Process of Necrotizing Fasciitis After Surgical Debridement.. Clinical and Laboratory Study.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- From pustule to flap: necrotizing fasciitis of the breast in type 1 diabetes-a case report.Journal of surgical case reports · 2026Article
- The role of negative-pressure wound therapy in Fournier's gangrene: Association with mortality.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Outcomes of vacuum-assisted closure therapy (VAC) in patients with Fournier's gangrene: a retrospective cohort study.Irish journal of medical science · 2026Article
- Results of surgical treatment of necrotizing soft tissue infections. A 15-years retrospective cohort study of a single center of emergency surgery.Langenbeck's archives of surgery · 2026Article
- Necrotizing Fasciitis in the Kimberley: A Five-Year Retrospective Study From a Remote Australian Health Service.Cureus · 2026Article
- Restoring Abdominal Integrity in Necrotizing Fasciitis Following Liposuction: A Case Report.Aesthetic plastic surgery · 2025Article
- Comparison between vacuum sealing drainage (VSD) and conventional dressing for fournier's gangrene: a single-centre retrospective study.BMC surgery · 2025Article
- Efficacy of hyperbaric oxygen therapy combine with negative pressure wound therapy in chronic wound: A randomized controlled trial.JPRAS open · 2025Article
- Complicated and deep bacterial skin and soft tissue infections.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Review
- A Rare Case of Necrotizing Fasciitis Presenting As Tarsal Tunnel Syndrome in a Patient With Uncontrolled Diabetes.Cureus · 2024Article
- Effectiveness of negative pressure wound therapy in complex surgical treatment of necrotizing fasciitis of the upper limb.World journal of orthopedics · 2024Article
- The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts.Journal of clinical medicine · 2023Review
- Article
- Necrotising fasciitis secondary to a perforated hepatic flexure tumour - A case report.International journal of surgery case reports · 2023Article
- Endogenous Biological Drivers in Diabetic Lower Limb Wounds Recurrence: Hypothetical Reflections.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNecrotizing fasciitis is a rapid and severe soft tissue infection that targets subcutaneous fat tissue, muscle, and fascia. This study compares the clinical outcomes of vacuum-assisted closure (VAC) versus conventional dressing on necrotizing fasciitis.
methodsWe systematically searched Embase, Cochrane, and PubMed for clinical trials (published between January 1, 1995 and September 30, 2021), which compared VAC with conventional dressing for necrotizing fasciitis. The mortality rate of necrotizing fasciitis was the primary outcome of this study. The number of debridements, the total length of hospital stay, and the complication rate were secondary outcomes. A random effects model assessed all pooled data.
resultsA total of 230 identified studies and seven controlled clinical trials met the inclusion criteria and were included in this analysis (n = 249 participants). Compared to the conventional dressing, patients treated with VAC had a significantly lower mortality rate [OR = 0.27, 95% CI (0.09, 0.87)] (P = 0.03). Total length of hospital stays [MD = 8.46, 95% CI (- 0.53, 17.45)] (P = 0.07), number of debridements [MD = 0.86, 95% CI (- 0.58, 2.30)] (P = 0.24), and complication rate [OR = 0.64, 95% CI (0.07, 5.94)] (P = 0.69) were not significant. These results did not show significant differences between both groups treated with VAC or conventional treatment.
conclusionVAC could significantly decrease the death rate compared to conventional dressing. No significant impacts were found on the number of debridements, the total length of hospital stay, and the complication rate in this study. Level of evidence Level-III. Registration Research Registry (reviewregistry1246).
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