ArticleNature communications2023
Rational design of N-heterocyclic compound classes via regenerative cyclization of diamines.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Advances in Perimidine Derivative Synthesis: From Classical Condensation to Dehydrogenative Coupling and Borrowing Hydrogen Strategies.Topics in current chemistry (Cham) · 2026Review
- Overcoming Data Starvation: Automated Virtual Reaction Exploration and Machine Learning Discovery of p-Block Metal Catalysts for Borrowing Hydrogen.Angewandte Chemie (International ed. in English) · 2026Article
- Molecularly Engineered Dual-Emission Pathways with Monomer-Excimer Interplay for Single-Component Blue and White Organic Light-Emitting Diodes.ACS applied optical materials · 2026Article
- Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review.Molecules (Basel, Switzerland) · 2025Review
- Diazines and Triazines as Building Blocks in Ligands for Metal-Mediated Catalytic Transformations.ACS organic & inorganic Au · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The discovery of reactions is a central topic in chemistry and especially interesting if access to compound classes, which have not yet been synthesized, is permitted. N-Heterocyclic compounds are very important due to their numerous applications in life and material science. We introduce here a consecutive three-component reaction, classes of N-heterocyclic compounds, and the associated synthesis concept (regenerative cyclisation). Our reaction starts with a diamine, which reacts with an amino alcohol via dehydrogenation, condensation, and cyclisation to form a new pair of amines that undergoes ring closure with an aldehyde, carbonyldiimidazole, or a dehydrogenated amino alcohol. Hydrogen is liberated in the first reaction step and the dehydrogenation catalyst used is based on manganese.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.