ArticleNPJ microgravity2023
Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts.
Article in NPJ microgravity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2026Pooled it
- Artificial gravity during prolonged bed rest preserves resting metabolic rate but not muscle function: Evidence from the BRACE study.The Journal of physiology · 2026Trial
- Limited musculoskeletal benefits of artificial gravity combined with cycling during bed rest: Results from the BRACE study.Experimental physiology · 2026Trial
- Quantitative MRI changes in neck muscle size and composition following long-duration spaceflight.Experimental physiology · 2026Article
- Jumping on the moon as a potential exercise countermeasure.Experimental physiology · 2026Article
- Entering a new era for exercise countermeasures in human spaceflight.Experimental physiology · 2026Article
- The physiology of survival: Space.Experimental physiology · 2026Article
- Spaceflight and sport science: Physiological monitoring and countermeasures for the astronaut-athlete on Mars exploration missions.Experimental physiology · 2026Review
- Decoding the space integrome: Personalized countermeasures for a mission to Mars.Experimental physiology · 2026Article
- The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long-duration spaceflight.Experimental physiology · 2026Review
- Longitudinal alterations in lower extremity quantitative MRI metrics under simulated microgravity and their associations with systemic biomarkers.NPJ microgravity · 2026Article
- Jumping in simulated lunar gravity with blood flow restriction as a potential exercise countermeasure: The acute physiological effects.Experimental physiology · 2026Article
- Article
- A systematic review identifying fitness metrics indicative of simulated astronaut extravehicular activity task performance.NPJ microgravity · 2026Article
- The effect of spaceflight and simulated microgravity exposure on thermoregulation in humans: a systematic review.NPJ microgravity · 2026Article
- Bed rest decreases resting skeletal muscle OExperimental physiology · 2026Article
- Physical exercise protects cardiovascular fitness in long-term spaceflight: what have we learned?Science China. Life sciences · 2026Review
- Whole-body periodic acceleration: a new countermeasure against bone loss induced by long-term hindlimb unloading.European journal of applied physiology · 2026Article
- A scalable, hyperstable intelligent fibre velocimeter for dynamic digitization of resistance training.National science review · 2026Article
- The case for space as a model of accelerated aging.Nature aging · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Exercise training is a key countermeasure used to offset spaceflight-induced multisystem deconditioning. Here, we evaluated the effects of exercise countermeasures on multisystem function in a large cohort (N = 46) of astronauts on long-duration spaceflight missions. We found that during 178 ± 48 d of spaceflight, ~600 min/wk of aerobic and resistance exercise did not fully protect against multisystem deconditioning. However, substantial inter-individual heterogeneity in multisystem response was apparent with changes from pre to postflight ranging from -30% to +5%. We estimated that up to 17% of astronauts would experience performance-limiting deconditioning if current exercise countermeasures were used on future spaceflight missions. These findings support the need for refinement of current countermeasures, adjunct interventions, or enhanced requirements for preflight physiologic and functional capacity for the protection of astronaut health and performance during exploration missions to the moon and beyond.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.