ArticleJACC. Heart failure2023
Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study.
Article in JACC. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Loneliness among adults at the end of life: A systematic review of prevalence and correlates.Palliative medicine · 2026Pooled it
- Social relationships and risk of cardio-cerebrovascular diseases: a meta-analysis of longitudinal cohort studies.Social psychiatry and psychiatric epidemiology · 2026Pooled it
- Loneliness and Its Associated Factors in Individuals With Intellectual Disability and Borderline Intellectual Functioning: A Systematic Review.Journal of applied research in intellectual disabilities : JARID · 2026Pooled it
- Blood pressure variability and frailty: mechanisms, evidence, and clinical implications.International urology and nephrology · 2026Review
- The social context and environment as targets for heart failure prevention.Heart failure reviews · 2026Review
- Association between questionnaire-based and accelerometer-based physical activity and the incidence of psychiatric disorders in people with loneliness or social isolation: findings from the UK Biobank.European archives of psychiatry and clinical neuroscience · 2026Article
- Investigating relationships between loneliness, social isolation and health.Nature communications · 2026Article
- Loneliness, traditional risk factor control, genetic predisposition, and development of musculoskeletal disorders.Rheumatology (Oxford, England) · 2026Article
- Association of social isolation and loneliness with incident cardiovascular diseases: results from a nationally prospective cohorts in China.Social psychiatry and psychiatric epidemiology · 2026Article
- Association between social isolation, loneliness and the incidence of irritable bowel syndrome: a prospective cohort study in the UK Biobank.Annals of general psychiatry · 2026Article
- Social Disconnection, Genetic Risk, and the Incidence of Degenerative Valvular Heart Disease: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Social Isolation Trajectories Spanning Childhood to Adulthood and Mortality Risk in CKM Syndrome: Evidence From CHARLS.Brain and behavior · 2026Article
- Social isolation and 59 common health conditions: insights from observational and genetics analyses.BMC medicine · 2026Article
- Social Isolation and Incidence of Chest Pain and Mortality in Older Adults of the United States Population: A Cross-Sectional Study From NHANES 2001-2018.Health science reports · 2026Article
- Social isolation and functional impairment trajectories in a diverse cohort of middle-aged and older adults in Northern California.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Observational
- Social Asymmetry and Risk of Morbidity and Mortality.JAMA network open · 2026Article
- Loneliness and cognitive aging: a brain-heart axis perspective on a modifiable risk.Frontiers in aging · 2026Review
- Associations of Life-Course Social Isolation Trajectories and Depressive Symptoms With the Risk of Incident Cardiovascular Disease: A Prospective Cohort Study.Depression and anxiety · 2026Article
- A nomogram for predicting oral frailty in older adults: a small-sample cross-sectional study in Anhui Province, China.Frontiers in public health · 2026Article
- The prevalence and influence of self-reported loneliness in the older with community-acquired pneumonia: a multi-center cohort study.BMC geriatrics · 2025Article
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14 authors at 6 institutions in 2 countries.
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Abstract
backgroundSocial isolation and loneliness have emerged as important risk factors for cardiovascular diseases, particularly during the coronavirus disease pandemic. However, it is unclear whether social isolation and loneliness had independent and joint associations with incident heart failure (HF).
objectivesThis study sought to examine the association of social isolation, loneliness, and their combination with incident HF.
methodsThe UK Biobank study is a population-based cohort study. Social isolation and loneliness were assessed using self-reported questionnaires. HF cases were identified by linking hospital records and death registries. The weighted polygenic risk score associated with HF was calculated.
resultsAmong the 464,773 participants (mean age: 56.5 ± 8.1 years, 45.3% male), 12,898 incident HF cases were documented during a median follow-up of 12.3 years. Social isolation (most vs least: adjusted HR: 1.17; 95% CI:1.11-1.23) and loneliness (yes vs no: adjusted HR: 1.19; 95% CI: 1.11-1.27) were significantly associated with an increased risk of incident HF. The association between an elevated risk of HF and social isolation was modified by loneliness (P
conclusionsSocial isolation and loneliness were independently associated with a higher likelihood of incident HF regardless of genetic risk. The association between social isolation and incident HF was potentially modified by loneliness status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.