Evidence map›Paper›PMID 36737245›Full record

ReviewJournal of neurology, neurosurgery, and psychiatry2023

Sean W Willemse, Peter Harley, Ruben P A van Eijk, Koen C Demaegd, Pavol Zelina, R Jeroen Pasterkamp, Philip van Damme, Caroline Ingre, Wouter van Rheenen, Jan H Veldink and 5 more

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of neurology, neurosurgery, and psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Novel Potential Risk Loci for Migraine in the Portuguese Population.International journal of molecular sciences · 2026
    Article
  4. TDP-43: [GU]-ardian of the transcriptome.Molecular neurodegeneration · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. ALS: a field in motion.Scientific reports · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Genes & diseases · 2025
    Article
  18. Article
  19. Article
  20. Combined impact ofFrontiers in neurology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 7 countries.

Sean W WillemseDepartment of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.ORCID 0000-0002-0198-5740
Peter HarleyUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
Ruben P A van EijkDepartment of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.ORCID 0000-0002-7132-5967
Koen C DemaegdDepartment of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Pavol ZelinaDepartment of Translational Neuroscience, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.
R Jeroen PasterkampDepartment of Translational Neuroscience, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Philip van DammeDepartment of Neurology, KU Leuven Hospital, Leuven, Belgium.ORCID 0000-0002-4010-2357
Caroline IngreDepartment of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Wouter van RheenenDepartment of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Jan H VeldinkDepartment of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.ORCID 0000-0001-5572-9657
Matthew C KiernanBushell Chair of Neurology, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-9054-026X
Ammar Al-ChalabiDepartment of Neurology, King's College Hospital, London, UK.ORCID 0000-0002-4924-7712
Leonard H van den BergDepartment of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Pietro FrattaUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
Michael A van EsDepartment of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands M.A.vanEs@umcutrecht.nl.
University Medical Center Utrecht · NLNational Hospital for Neurology and Neurosurgery · GBKarolinska Institutet · SEKing's College Hospital · GBThe University of Sydney · AUVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

Medical Research Council MR/M008606/1Medical Research Council MR/R024804/1Medical Research Council MR/S006508/1Medical Research Council MR/W005190/1Motor Neurone Disease Association ALCHALABI-DOBSON/APR14/829-791
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options and an incompletely understood pathophysiology. Although genomewide association studies (GWAS) have advanced our understanding of the disease, the precise manner in which risk polymorphisms contribute to disease pathogenesis remains unclear. Of relevance, GWAS have shown that a polymorphism (rs12608932) in the

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaNeurodegenerative DiseasesHumansNerve Tissue ProteinsPolymorphism, GeneticNerve Tissue ProteinsALSfrontotemporal dementianeurobiologyneurogeneticsneuromuscular

Identifiers

PMID36737245
PMCPMC10359588
OpenAlexW4319071338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.