Evidence map›Paper›PMID 36737097›Full record

ArticleBMJ open2023

Mobilisation in the EveNing to TreAt deLirium (MENTAL): protocol for a mixed-methods feasibility randomised controlled trial.

David McWilliams, Elizabeth King, Peter Nydahl, Julie Lorraine Darbyshire, L Gallie, Dalia Barghouthy, C Bassford, Owen Gustafson

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05401461 (Does Mobilisation in the Evening Reduce the Incidence of Delirium in Patients Admitted to Intensive Care), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05401461 nacompletednot on this map

Does Mobilisation in the Evening Reduce the Incidence of Delirium in Patients Admitted to Intensive Care: a Mixed-methods, Randomised Controlled Feasibility Study

TypeinterventionalSponsorUniversity Hospitals Coventry and Warwickshire NHS TrustRan2022 to 2022Enrolled58ConditionsCritical Illness, Sleep Disturbance, Mobility Limitation, Intensive Care Unit DeliriumArmsEvening mobilisation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Exercise therapy for the treatment of delirium in the intensive care unit.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David McWilliamsCentre for Care Excellence, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK david.mcwilliams@uhcw.nhs.uk.ORCID 0000-0002-9086-2557
Elizabeth KingAdult Intensive Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Peter NydahlNursing Research, Universitatsklinikum Schleswig-Holstein, Kiel, Germany.ORCID 0000-0002-5178-0364
Julie Lorraine DarbyshireNuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.
L GalliePatient Representative, Plymouth, UK.
Dalia BarghouthyCritical Care, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
C BassfordCritical Care, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
Owen GustafsonOxford Allied Health Professions Research & Innovation Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0002-5450-3696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDelirium is common in critically ill patients and is associated with longer hospital stays, increased mortality and higher healthcare costs. A number of risk factors have been identified for the development of delirium in intensive care, two of which are sleep disturbance and immobilisation. Non-pharmacological interventions for the management of intensive care unit (ICU) delirium have been advocated, including sleep protocols and early mobilisation. However, there is a little published evidence evaluating the feasibility and acceptability of evening mobilisation. METHODS AND ANALYSIS: Mobilisation in the EveNing to TreAt deLirium (MENTAL) is a two-centre, mixed-methods feasibility randomised controlled trial (RCT). Sixty patients will be recruited from ICUs at two acute NHS trusts and randomised on a 1:1 basis to receive additional evening mobilisation, delivered between 19:00 and 21:00, or standard care. The underpinning hypothesis is that the physical exertion associated with evening mobilisation will promote better sleep, subsequently having the potential to reduce delirium incidence. The primary objective is to assess the feasibility and acceptability of a future, multicentre RCT. The primary outcome measures, which will determine feasibility, are recruitment and retention rates, and intervention fidelity. Acceptability of the intervention will be evaluated through semi-structured interviews of participants and staff. Secondary outcome measures include collecting baseline, clinical and outcome data to inform the power calculations of a future definitive trial. ETHICS AND DISSEMINATION: Ethical approval has been obtained through the Wales Research and Ethics Committee 6 (22/WA/0106). Participants are required to provide written informed consent. We aim to disseminate the findings through international conferences, international peer-reviewed journals and social media. TRIAL REGISTRATION NUMBER: NCT05401461.

Indexed as

DeliriumCritical CareFeasibility StudiesHumansIntensive Care UnitsPhysical Therapy ModalitiesRandomized Controlled Trials as TopicDelirium & cognitive disordersINTENSIVE & CRITICAL CAREREHABILITATION MEDICINESLEEP MEDICINE

Identifiers

PMID36737097
PMCPMC9900058

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.