Evidence map›Paper›PMID 36737001›Full record

Observational studyThe Canadian journal of cardiology2023

Regional Differences in Outcomes for Patients Undergoing Transcatheter Aortic Valve Replacement in New York State and Ontario.

Harindra C Wijeysundera, Mario Gaudino, Feng Qiu, Molly A Olson, Jialin Mao, Ragavie Manoragavan, Lisa Rong, Derrick Y Tam, Peter C Austin, Stephen E Fremes and 1 more

Abstract readObservational Study
In one paragraph

Observational study in The Canadian journal of cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Harindra C WijeysunderaInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: harindra.wijeysundera@sunnybrook.ca.
Mario GaudinoDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York, USA.
Feng QiuInstitute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Molly A OlsonDepartment of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York, USA.
Jialin MaoDepartment of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York, USA.
Ragavie ManoragavanSchulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Lisa RongDepartment of Anesthesiology, Weill Cornell Medicine, New York, New York, USA.
Derrick Y TamInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Schulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Peter C AustinInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Stephen E FremesSchulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Art SedrakyanDepartment of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York, USA.

Funding

Novel Approaches to Advance Coordinated Registry Networks (CRNs).U01FD006936 · FDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI SEDRAKYAN, ART · 2020 to 2022
$2.1M
Leveraging linked registry and electronic health records to examine long-term patient outcomes after peripheral vascular intervention"K01HL159315 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MAO, JIALIN · 2021 to 2025
$810k
FDA HHS U01 FD006936NHLBI NIH HHS K01 HL159315
6 · The paper itself

Abstract

backgroundTranscatheter aortic valve replacement (TAVR) has become the standard of care for a wide spectrum of patients with severe aortic stenosis. However, there are wide variations in access to TAVR among jurisdictions. It is unknown if such variation is associated with differences in postprocedural outcomes. Our objective was to determine whether differences in health care delivery in jurisdictions with high vs low access of care to TAVR translate to differences in postprocedural outcomes.

methodsIn this observational, retrospective cohort study, we identified all Ontario and New York State residents greater than 18 years of age who received TAVR from January 1, 2012, to December 31, 2018. Our primary outcomes were post-TAVR 30 day in-hospital mortality and all-cause readmissions. Using indirect standardization, we calculated the observed vs expected outcomes for New York patients, had they been treated in Ontario.

resultsOur cohort consisted of 16,814 TAVR patients at 36 hospitals in New York State and 5007 TAVR patients at 11 hospitals in Ontario. In Ontario, TAVR access rates increased from ∼18.2 TAVR per million in 2012 to 87.4 TAVR per million in 2018, whereas for New York State, the rates increased from 31.9 to 220.4 TAVR per million. For 30-day mortality, 3.1% of Ontario TAVR patients had an in-hospital death, compared with 2.5% of New York patients. With adjustment, this translated to an observed-expected ratio of 0.70 (95% confidence interval [CI], 0.54-0.92) for New York patients.

conclusionsHaving greater access to TAVR may be associated with improved outcomes, potentially because of intervention earlier in the trajectory of the disease.

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementAortic ValveHospital MortalityHumansNew YorkOntarioRetrospective StudiesRisk FactorsTreatment Outcome

Identifiers

PMID36737001
PMCPMC11116973

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.