ArticleAgeing research reviews2023
Dysregulation of polarity proteins in astrocyte reactivity.
Article in Ageing research reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Nitric Oxide-S-Nitrosylation and Its Role in Neuroinflammation Associated with Neuropsychiatric Conditions.International journal of molecular sciences · 2026Review
- Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis.Nature cell biology · 2023Article
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Authors and funding
1 author.
Funding
Abstract
Astrocytes are highly polarized neuroglial cells. Polarity is the basis for many of the diverse roles that astrocytes play in the normal and injured brain. Astrocytes are generally dormant and non-migratory under normal physiological conditions, where they perform a wide variety of intricate and essential tasks in preserving CNS homeostasis. In response to pathological insults, astrocytes shift from the normal dormant and homeostatic state to a reactive and migratory state through a process referred to as "reactive astrogliosis". Cell polarity proteins play a key role in the initiation and regulation of migration. Recent evidence suggests that cell polarity proteins are dysregulated during astrogliosis and may modulate astrocyte reactivity and alter the course of disease. Therefore, cell polarity proteins may provide novel therapeutic targets for modulating astrocyte reactivity in brain disorders.
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