Evidence map›Paper›PMID 36736326›Full record

ArticleStem cell reports2023

Generation of functional human T cell development in NOD/SCID/IL2rγ

Chloé Colas, Olga Volodina, Kathie Béland, Tram N Q Pham, Yuanyi Li, Frédéric Dallaire, Clara Soulard, William Lemieux, Aurélien B L Colamartino, Camille Tremblay-Laganière and 7 more

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Chloé ColasDepartment of Microbiology and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada; CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
Olga VolodinaMontreal Clinical Research Institute (IRCM), Montreal, QC H2W 1R7, Canada.
Kathie BélandCHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
Tram N Q PhamDepartment of Microbiology and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada; Montreal Clinical Research Institute (IRCM), Montreal, QC H2W 1R7, Canada.
Yuanyi LiCHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
Frédéric DallaireMontreal Clinical Research Institute (IRCM), Montreal, QC H2W 1R7, Canada.
Clara SoulardDepartment of Microbiology and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada; CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
William LemieuxDepartment of Microbiology and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada; CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
Aurélien B L ColamartinoDepartment of Microbiology and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada; CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
Camille Tremblay-LaganièreDepartment of Microbiology and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada; CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
Renée DicaireCHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
Jean GuimondCSSS Jeanne Mance, Montreal, QC H2X 1K6, Canada.
Suzanne VobeckyDepartment of Cardiac Surgery, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Nancy PoirierDepartment of Cardiac Surgery, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Natasha PateyCHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada; Department of Pathology, CHU Sainte-Justine, Université de Montréal, Montreal, QC H3T 1C5, Canada.
Éric A CohenDepartment of Microbiology and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada; Montreal Clinical Research Institute (IRCM), Montreal, QC H2W 1R7, Canada. Electronic address: eric.cohen@ircm.qc.ca.
Elie HaddadDepartment of Microbiology and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada; CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada; Department of Pediatrics, Université de Montréal, Montreal, QC H3T 1C5, Canada. Electronic address: elie.haddad@umontreal.ca.
Centre Hospitalier Universitaire Sainte-Justine · CAMontreal Clinical Research Institute · CACentre de Santé et de Services Sociaux Cavendish · CA

Funding

CIHR HB2-164064
6 · The paper itself

Abstract

Humanization of mice with functional T cells currently relies on co-implantation of hematopoietic stem cells from fetal liver and autologous fetal thymic tissue (so-called BLT mouse model). Here, we show that NOD/SCID/IL2rγ

Indexed as

HIV InfectionsAnimalsChildDisease Models, AnimalHumansMiceMice, Inbred NODMice, KnockoutMice, SCIDThymus GlandT-Lymphocytesfunctional T cellshematopoietic stem cellsHIVhumanized mouse modelthymus

Identifiers

PMID36736326
PMCPMC9969074
OpenAlexW4318986664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.