Evidence map›Paper›PMID 36736311›Full record

ReviewMolecular cell2023

Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing.

Howard Y Chang, Lei S Qi

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Central Dogma Cycle and Network: A Model for Cell Memory.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
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  12. Review
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  16. Article
  17. Article
  18. PlantIntronDB: a database for plant introns that host functional elements.Database : the journal of biological databases and curation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Howard Y ChangCenter for Personal Dynamic Regulome, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: howchang@stanford.edu.
Lei S QiDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94080, USA. Electronic address: slqi@stanford.edu.
Chan Zuckerberg Initiative (United States) · USHoward Hughes Medical Institute · US

Funding

Center for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8M
LncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4M
High resolution dissection of oncogene enhancer networks via CRISPR screening and live-cell imaging.R01CA266470 · NCI · STANFORD UNIVERSITY · PI Lei Stanley Qi · 2022 to 2026
$1.9M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA266470NCI NIH HHS R35 CA209919NHGRI NIH HHS RM1 HG007735
6 · The paper itself

Abstract

The Central Dogma of the flow of genetic information is arguably the crowning achievement of 20

Indexed as

Gene EditingRNA, Long NoncodingAnimalsChromatinCRISPR-Cas SystemsDNAEpigenesis, GeneticMammalsChromatinDNARNA, Long Noncoding

Identifiers

PMID36736311
PMCPMC10044466
OpenAlexW4318985510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.