Evidence map›Paper›PMID 36735689›Full record

ArticlePloS one2023

Escalating spread of SARS-CoV-2 infection after school reopening among students in hotspot districts of Oromia Region in Ethiopia: Longitudinal study.

Dabesa Gobena, Esayas Kebede Gudina, Daniel Yilma, Tsinuel Girma, Getu Gebre, Tesfaye Gelanew, Alemseged Abdissa, Daba Mulleta, Tarekegn Sarbessa, Henok Asefa and 8 more

Expression of concernOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Dabesa GobenaPublic Health Emergency Management and Health Research Directorate, Oromia Health Bureau, Addis Ababa, Ethiopia.ORCID 0000-0002-7222-2839
Esayas Kebede GudinaDepartment of Internal Medicine, Jimma University, Jimma, Ethiopia.
Daniel YilmaDepartment of Internal Medicine, Jimma University, Jimma, Ethiopia.
Tsinuel GirmaFenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.
Getu GebrePublic Health Emergency Management and Health Research Directorate, Oromia Health Bureau, Addis Ababa, Ethiopia.
Tesfaye GelanewArmauer Hanssen Research Institute, Addis Ababa, Ethiopia.
Alemseged AbdissaArmauer Hanssen Research Institute, Addis Ababa, Ethiopia.
Daba MulletaPublic Health Emergency Management and Health Research Directorate, Oromia Health Bureau, Addis Ababa, Ethiopia.
Tarekegn SarbessaPublic Health Emergency Management and Health Research Directorate, Oromia Health Bureau, Addis Ababa, Ethiopia.
Henok AsefaDepartment of Epidemiology, Jimma University, Jimma, Ethiopia.
Mirkuzie WoldieFenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.
Gemechu ShumiFenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.
Birhanu KenateFenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.
Arne KroidlDivision of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Munich, Germany.
Andreas WieserDivision of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Munich, Germany.
Beza EshetuDepartment of Pediatrics and Child Health, Jimma University, Jimma, Ethiopia.
Tizta Tilahun DegfieFenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.ORCID 0000-0002-3842-9844
Zeleke MekonnenSchool of Medical Laboratory Science, Institute of Health, Jimma University, Jimma, Ethiopia.
Jimma University · ETAddis Ababa University · ETOromiyaa Regional Health Bureau · ETArmauer Hansen Research Institute · ETGerman Center for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19 pandemic caused by extended variants of SARS-CoV-2 has infected more than 350 million people, resulting in over 5.5 million deaths globally. However, the actual burden of the pandemic in Africa, particularly among children, remains largely unknown. We aimed to assess the seroepidemiological changes of SARS-CoV-2 infection after school reopening among school children in Oromia, Ethiopia.

methodsA prospective cohort study involving students aged 10 years and older were used. A serological survey was performed twice, at school reopening in December 2020 and four months later in April 2021. Participants were selected from 60 schools located in 15 COVID-19 hotspot districts in Oromia Region. Serology tests were performed by Elecsys anti-SARS-CoV-2 nucleocapsid assay. Data were collected using CSentry CSProData Entry 7.2.1 and exported to STATA version 14.2 for data cleaning and analysis.

resultsA total of 1884 students were recruited at baseline, and 1271 completed the follow-up. SARS-CoV-2 seroprevalence almost doubled in four months from 25.7% at baseline to 46.3% in the second round, with a corresponding seroincidence of 1910 per 100,000 person-week. Seroincidence was found to be higher among secondary school students (grade 9-12) compared to primary school students (grade 4-8) (RR = 1.6, 95% CI 1.21-2.22) and among those with large family size (> = 5) than those with a family size of <3 (RR = 2.1, 95% CI 1.09-4.17). The increase in SARS-CoV-2 seroprevalence among the students corresponded with Ethiopia's second wave of the COVID-19 outbreak.

conclusionSARS-CoV-2 seroprevalence among students in hotspot districts of the Oromia Region was high even at baseline and almost doubled within four months of school recommencement. The high seroincidence coincided with the second wave of the COVID-19 outbreak in Ethiopia, indicating a possible contribution to school opening for the new outbreak wave.

Indexed as

COVID-19ChildEthiopiaHumansLongitudinal StudiesPandemicsProspective StudiesSARS-CoV-2SchoolsSeroepidemiologic StudiesStudents

Identifiers

PMID36735689
PMCPMC9897530
OpenAlexW4319062756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.