Evidence map›Paper›PMID 36735500›Full record

SynthesisNeurosurgery2023

Long-Term Hearing Outcome After Radiosurgery for Vestibular Schwannoma: A Systematic Review and Meta-Analysis.

Anne Balossier, Constantin Tuleasca, Christine Delsanti, Lucas Troude, Jean-Marc Thomassin, Pierre-Hugues Roche, Jean Régis

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 7 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 7 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  5. Long-Term Hearing Outcome For Vestibular Schwannomas After Microsurgery And Radiotherapy: A Systematic Review and Meta-Analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024
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  13. [ACOUNEU-radiosurgery or hypofractionated radiotherapy for sporadic vestibular schwannoma].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Anne BalossierAP-HM, Timone Hospital, Functional and Stereotactic Neurosurgery, Marseille, France.
Constantin TuleascaCentre Hospitalier Universitaire Vaudois (CHUV), Neurosurgery Service and Gamma Knife Center, Lausanne, Switzerland.
Christine DelsantiAP-HM, Timone Hospital, Functional and Stereotactic Neurosurgery, Marseille, France.
Lucas TroudeAP-HM, North University Hospital, Department of Neurosurgery, Marseille, France.
Jean-Marc ThomassinDepartment of Head and Neck Surgery, AP-HM, Timone Hospital, Marseille, France.
Pierre-Hugues RocheAP-HM, North University Hospital, Department of Neurosurgery, Marseille, France.
Jean RégisAP-HM, Timone Hospital, Functional and Stereotactic Neurosurgery, Marseille, France.
Assistance Publique Hôpitaux de Marseille · FRHôpital de la Timone · FRÉcole Polytechnique Fédérale de Lausanne · CHInserm · FRInstitut de Neurosciences des Systèmes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStereotactic radiosurgery (SRS) is one of the main treatment options in the management of small to medium size vestibular schwannomas (VSs), because of high tumor control rate and low cranial nerves morbidity. Series reporting long-term hearing outcome (>3 years) are scarce.

objectiveTo perform a systematic review of the literature and meta-analysis, with the aim of focusing on long-term hearing preservation after SRS.

methodsUsing Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we reviewed articles published between January 1990 and October 2020 and referenced in PubMed or Embase. Inclusion criteria were peer-reviewed clinical study or case series of VSs treated with SRS (single dose), reporting hearing outcome after SRS with a median or mean audiometric follow-up of at least 5 years. Hearing preservation, cranial nerves outcomes, and tumor control were evaluated.

resultsTwenty-three studies were included. Hearing preservation was found in 59.4% of cases (median follow-up 6.7 years, 1409 patients). Main favorable prognostic factors were young age, good hearing status, early treatment after diagnosis, small tumor volume, low marginal irradiation dose, and maximal dose to the cochlea. Tumor control was achieved in 96.1%. Facial nerve deficit and trigeminal neuropathy were found in 1.3% and 3.2% of patients, respectively, both significantly higher in Linear Accelerator series than Gamma Knife series ( P < .05).

conclusionLong-term hearing preservation remains one of the main issues after SRS, with a major impact on health-related quality of life. Our meta-analysis suggests that hearing preservation can be achieved in almost 60% of patients after a median follow-up of 6.7 years, irrespective of the technique.

Indexed as

Neuroma, AcousticRadiosurgeryFollow-Up StudiesHearingHumansQuality of LifeRetrospective StudiesTreatment Outcome

Identifiers

PMID36735500
PMCPMC10150847
OpenAlexW4319058498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.