Evidence map›Paper›PMID 36735402›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.

Surawee Chuaiphichai, Sandy M Chu, Ricardo Carnicer, Matthew Kelly, Jenifer K Bendall, Jillian N Simon, Gillian Douglas, Mark J Crabtree, Barbara Casadei, Keith M Channon

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 11 citations in OpenAlex.

  1. Molecular Mechanisms Governing Vascular Function in Heart Failure.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Inducible EndothelialHypertension (Dallas, Tex. : 1979) · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Multiple Shades of Gray-Macrophages in Acute Allograft Rejection.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Surawee ChuaiphichaiDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7512-6252
Sandy M ChuDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Ricardo CarnicerDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Matthew KellyDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jenifer K BendallDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jillian N SimonCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, United States.ORCID 0000-0001-8140-7782
Gillian DouglasDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Mark J CrabtreeDepartment of Biochemical Sciences, School of Bioscience and Medicine, University of Surrey, Guildford, United Kingdom.
Barbara CasadeiDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6801-1617
Keith M ChannonDivision of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-1043-4342
British Heart Foundation · GBTemple University · USUniversity of Surrey · GB

Funding

British Heart Foundation CH/12/3/29609British Heart Foundation CH/16/1/32013British Heart Foundation FS/14/56/31049British Heart Foundation PG/15/35/31403British Heart Foundation PG/19/48/34433British Heart Foundation RE/13/1/30181British Heart Foundation RG/12/5/29576British Heart Foundation RG/16/12/32451British Heart Foundation RG/17/10/32859British Heart Foundation RG/F/22/110085Department of HealthWellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

The cofactor tetrahydrobiopterin (BH

Indexed as

Heart FailureMyocardial InfarctionMyocardial Reperfusion InjuryAnimalsBiopterinsCardiomegalyEndothelial CellsGTP CyclohydrolaseMiceMice, KnockoutMyocardiumMyocytes, CardiacNitric OxideNitric Oxide Synthase Type IIIBiopterinsGTP CyclohydrolaseNitric OxideNitric Oxide Synthase Type IIIsapropterincardiac functionhypertrophyischemia-reperfusion injurynitric oxide synthasetetrahydrobiopterin

Identifiers

PMID36735402
PMCPMC9988535
OpenAlexW4319063760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.