Evidence map›Paper›PMID 36735157›Full record

Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2023

Comparison of perioperative outcomes between bipolar sealing, ultrasonic shears and a hybrid device during laparoscopic gastrectomy for early gastric cancer: a prospective, multicenter, randomized study.

Ji-Hyeon Park, Seong-Ho Kong, Felix Berlth, Jong-Ho Choi, Sara Kim, Sa-Hong Kim, So Hyun Kang, Sangjun Lee, Jaeun Yoo, Eunhee Goo and 9 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ji-Hyeon ParkDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Seong-Ho KongDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea. seongho.kong@snu.ac.kr.ORCID http://orcid.org/0000-0002-3929-796X
Felix BerlthDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Jong-Ho ChoiDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Sara KimDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Sa-Hong KimDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
So Hyun KangDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.
Sangjun LeeDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.
Jaeun YooCancer Research Institute, Seoul National University, Seoul, South Korea.
Eunhee GooCancer Research Institute, Seoul National University, Seoul, South Korea.
Kyoungyun JeongCancer Research Institute, Seoul National University, Seoul, South Korea.
Hyun Myong KimCancer Research Institute, Seoul National University, Seoul, South Korea.
Young Suk ParkDepartment of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Sang-Hoon AhnDepartment of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Yun-Suhk SuhDepartment of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Do Joong ParkDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Hyuk-Joon LeeDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.
Hyung-Ho KimDepartment of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Han-Kwang YangDepartment of Surgery, Seoul National University Hospital, Seoul, South Korea.

Funding

Medtronic 0620173830
6 · The paper itself

Abstract

backgroundAlthough EBDs are essential for minimally invasive surgery, well-established prospective randomized studies comparing EBDs are scarce. This study aimed to compare the intraoperative inflammatory response and short-term surgical outcomes among different energy-based devices (EBDs) in laparoscopic distal gastrectomy (LDG).

methodsPatients with clinical stage I gastric cancer scheduled for LDG at two different medical centers were prospectively randomized into three groups: ultrasonic shears (US), advanced bipolar (BP) and ultrasonic-bipolar hybrid (HB). The C-reactive protein (CRP) level, operation time, intraoperative blood loss (IBL), laboratory tests, cytokines (interleukin (IL)-6 and IL-10), hospital stay, and complication rate were analyzed. A novel semiquantitative measurement method using indocyanine green (ICG) and a near-infrared camera measured the amount of lymphatic leakage.

resultsThe primary endpoint, the CRP level, was significantly lower in the BP (n = 60) group than in the US (n = 57) or HB (n = 57) group [9.03 ± 5.55 vs. 11.12 ± 5.02 vs. 12.67 ± 6.14, p = 0.001, on postoperative day (POD) 2 and 7.48 vs. 9.62 vs. 9.48, p = 0.026, on POD 4]. IBL was significantly lower in BP than in US or HB (26.3 ± 25.3 vs. 43.7 ± 42.0 vs. 34.9 ± 37.0, p = 0.032). Jackson-Pratt drainage triglycerides were significantly lower in BP than in US (53.6 ± 33.7 vs. 84.2 ± 59.0, p = 0.11; HB: 71.3 ± 51.4). ICG fluorescence intensity, operation time, laboratory results, cytokines, hospital stay, and complication rate were not significantly different among the 3 groups.

conclusionBP showed a lower postoperative CRP level and less IBL than US and HB, suggesting less collateral thermal damage and better sealing function. Surgeons may consider this when selecting EBDs for laparoscopic surgery.

Indexed as

LaparoscopyStomach NeoplasmsGastrectomyHumansIndocyanine GreenInterleukin-10Prospective StudiesRetrospective StudiesTreatment OutcomeUltrasonicsIndocyanine GreenInterleukin-10BipolarEarly gastric cancerEnergy devicesLaparoscopy gastrectomyUltrasonic

Identifiers

PMID36735157

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.