ArticleInternational urology and nephrology2023
Age-adjusted reference values and influencing factors of cystatin C in healthy Chinese population.
Article in International urology and nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Updated reference intervals for serum cystatin C and creatinine based on age and sex variations.Scientific reports · 2025Article
- Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients.Frontiers in neuroscience · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNormative distribution of serum cystatin C and relationship with sex and age in healthy adult Chinese population is unknown.
methodsThis is a prospective cohort study. Adult subjects (18 years of age and older) who underwent annual health examination at the Health Management Center in Sir Run Run Hospital were eligible. Subjects with major diseases, e.g., hypertension, diabetes, chronic kidney disease, obesity (body mass index ≥ 28 kg/m
resultsThe final analysis included a total of 10,640 subjects (40 ± 12 years, 52% men). The median serum cystatin C concentration was 0.73 mg/L (95% CI 0.52-1.03 mg/L) in the overall analysis, 0.79 (95% CI 0.59-1.07 mg/L) in men, and 0.67 (95% CI 0.49-0.95 mg/L) in women. In the multivariate regression analysis, elevated cystatin C was independently associated with the male sex (odds ratio 1.94; 95% CI 1.07-3.52), older age (odds ratio 1.04 every year; 95% CI 1.02-1.06), higher body mass index (odds ratio 1.70; 95% CI 1.01-2.83), uric acid (odds ratio 1.00; 95% CI 1.00-1.01), and β2-microglobulin (odds ratio 39.35; 95% CI 22.90-67.64).
conclusionThe median serum cystatin C concentration was 0.73 (95% CI 0.52-1.03 mg/L) in healthy adult Chinese population, 0.79 (95% CI 0.59-1.07 mg/L) in men, and 0.67 (95% CI 0.49-0.95 mg/L) in women. Elevated cystatin C was associated with the male sex, older age and higher body mass index.
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