Evidence map›Paper›PMID 36735025›Full record

ArticleChemical communications (Cambridge, England)2023

Masking thiol reactivity with thioamide, thiourea, and thiocarbamate-based MBPs.

Hyeonglim Seo, Alysia J Kohlbrand, Ryjul W Stokes, Jeewon Chung, Seth M Cohen

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Synthesis and crystal structure analysis of bis-(benzo-thia-zole-2-thiol-ato-κActa crystallographica. Section E, Crystallographic communications · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Hyeonglim SeoDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.ORCID http://orcid.org/0000-0002-2527-9293
Alysia J KohlbrandDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.
Ryjul W StokesDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.ORCID http://orcid.org/0000-0001-5965-5421
Jeewon ChungDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.
Seth M CohenDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.ORCID http://orcid.org/0000-0002-5233-2280

Funding

Metal-binding Isosteres for Influenza Endonuclease Inhibitors and BeyondR01AI149444 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SETH M COHEN · 2020 to 2026
$2.3M
NIAID NIH HHS R01 AI149444
6 · The paper itself

Abstract

Thioamides, thioureas, and thiocarbamates are introduced as stable, sulfur-based metal-binding pharmacophores (MBPs) for use in metalloenzyme fragment-based drug discovery (mFBDD). MBP reactivity, bioactivity, and structural studies show that these molecules can act as ligands for Zn(II)-dependent metalloenzymes including human carbonic anhydrase II (hCAII) and matrix metalloproteinase-2 (MMP-2).

Indexed as

MetalloproteinsThioureaChelating AgentsHumansMatrix Metalloproteinase 2Sulfhydryl CompoundsThioamidesThiocarbamatesChelating AgentsMatrix Metalloproteinase 2MetalloproteinsSulfhydryl CompoundsThioamidesThiocarbamatesThiourea

Identifiers

PMID36735025
PMCPMC10008514

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.