ArticleAging2023
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity.
Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Hypoglycemic mechanism of modified Gegen Qinlian decoction based on regulating the expression and DNA methylation of cholesterol transporters in the adipose tissue of type 2 diabetes mellitus rats.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Potential Noninvasive Biomarkers to Assess the Aging Process.Expert reviews in molecular medicine · 2025Review
- Developing a novel aging assessment model to uncover heterogeneity in organ aging and screening of aging-related drugs.Genome medicine · 2025Article
- Liver-specific expression of ANGPTL8 promotes Alzheimer's disease progression through activating microglial pyroptosis.Journal of neuroinflammation · 2025Article
- Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025Review
- Unraveling genetic causality between metformin and myocardial infarction on the basis of Mendelian randomization.Frontiers in endocrinology · 2024Article
- NSAIDs use history: impact on the genome-wide DNA methylation profile and possible mechanisms of action.Clinical and experimental medicine · 2023Article
- Exploring Molecular Targets for Mitochondrial Therapies in Neurodegenerative Diseases.International journal of molecular sciences · 2023Review
- Extended-release metformin improves cognitive impairment in frail older women with hypertension and diabetes: preliminary results from the LEOPARDESS Study.Cardiovascular diabetology · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetformin, a commonly prescribed anti-diabetic medication, has repeatedly been shown to hinder aging in pre-clinical models and to be associated with lower mortality for humans. It is, however, not well understood how metformin can potentially prolong lifespan from a biological standpoint. We hypothesized that metformin's potential mechanism of action for longevity is through its epigenetic modifications.
methodsTo test our hypothesis, we conducted a post-hoc analysis of available genome-wide DNA methylation (DNAm) data obtained from whole blood collected from inpatients with and without a history of metformin use. We assessed the methylation profile of 171 patients (first run) and only among 63 diabetic patients (second run) and compared the DNAm rates between metformin users and nonusers.
resultsEnrichment analysis from the Kyoto Encyclopedia of Genes and Genome (KEGG) showed pathways relevant to metformin's mechanism of action, such as longevity, AMPK, and inflammatory pathways. We also identified several pathways related to delirium whose risk factor is aging. Moreover, top hits from the Gene Ontology (GO) included HIF-1α pathways. However, no individual CpG site showed genome-wide statistical significance (
conclusionThis study may elucidate metformin's potential role in longevity through epigenetic modifications and other possible mechanisms of action.
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