Evidence map›Paper›PMID 36734627›Full record

Trial reportPharmacology research & perspectives2023

Safety, tolerability, and pharmacokinetics of single and multiple ascending Oral doses of DA-8010 in healthy subjects: First-in-human phase I study.

Dae Young Lee, Min Jung Lee, Chaelim Ryu, Heewon Lee, Ashley Brooks

Open access · goldAbstract readRandomized Controlled TrialClinical Trial, Phase I
In one paragraph

Trial report in Pharmacology research & perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Muscarinic control of cardiovascular function in humans: a review of current clinical evidence.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Dae Young LeeDong-A ST Research Center, Giheung-gu, South Korea.
Min Jung LeeDong-A ST Research Center, Giheung-gu, South Korea.
Chaelim RyuDong-A ST Research Center, Giheung-gu, South Korea.
Heewon LeeDong-A ST HQ, Seoul, South Korea.
Ashley BrooksLabcorp Drug Development, Clinical Research Unit Limited, Springfield House, West Yorkshire, UK.ORCID 0000-0002-9189-1114
Dong-A ST (South Korea) · KRLabCorp (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the safety, tolerability, and pharmacokinetics of single and multiple oral doses of DA-8010, a muscarinic M

Indexed as

DizzinessAdministration, OralArea Under CurveFemaleHealthy VolunteersHumansMalePhenylcarbamatesPyrrolidinesDA-8010PhenylcarbamatesPyrrolidinesdrug safetypharmacokineticsphase Irandomized controlled trial

Identifiers

PMID36734627
PMCPMC9897050
OpenAlexW4319061799

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.