ArticleAnaesthesiology intensive therapy2022
Mean systemic filling pressure indicates fluid responsiveness and anaesthesia-induced unstressed blood volume.
Article in Anaesthesiology intensive therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Comparison of oral water ingestion and intravenous fluid infusion on fluid responsiveness in healthy volunteers, a prospective, randomized trial.Scientific reports · 2026Trial
- Detection of hypovolemia by non-invasive hemodynamic monitoring during major surgery using Ringer´s solution, 5% albumin, or 20% albumin as infusion fluid: a post-hoc analysis of a randomized clinical trial.Critical care (London, England) · 2025Trial
- Do volatile anaesthetics depress urine output?Anaesthesiology intensive therapy · 2024Trial
- Influence of adrenergic drugs and volume loading on mean systemic filling pressure in non-septic and septic sheep.Frontiers in medicine · 2026Article
- Revisiting the fluid challenge and stroke volume optimisation after induction of general anaesthesia.Annals of intensive care · 2026Article
- Cardiovascular Safety of VIAN-c4551, an Antiangiogenic Peptide Derived From Vasoinhibin.Drug development research · 2025Article
- Venous excess ultrasound: A mini-review and practical guide for its application in critically ill patients.World journal of critical care medicine · 2025Review
- Perioperative fluid therapy in adults and children: a narrative review.Frontiers in medicine · 2025Review
- Mean Systemic Filling Pressure Was Associated with 28-Day Mortality in Patients with Constrictive Pericarditis After Pericardial Stripping: A Retrospective Cohort Study.International journal of general medicine · 2025Article
- Venous return physiology applied to post-cardiac arrest haemodynamic management: a post hoc analysis of the NEUROPROTECT trial.Intensive care medicine experimental · 2024Article
- Role of Crystalloids in the Perioperative Setting: From Basics to Clinical Applications and Enhanced Recovery Protocols.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe mean systemic filling pressure (Pms) plays a central role for our understanding of the circulation. In a retrospective analysis of a clinical trial, we studied whether Pms indicates fluid responsiveness and whether Pms can indicate an anaesthesia-induced increase of the unstressed blood volume, which is the volume that does not increase the transmural pressure.
methodsAn analogue to P ms based on cardiac output, the mean arterial pressure and the central venous pressure, abbreviated to P msa , were calculated in 86 patients before induction of general anaesthesia and before 3 successive bolus infusions of 3 mL kg -1 of colloid fluid. An increase in stroke volume of ≥ 10% from a bolus infusion indicated fluid responsiveness. Receiver operator characteristic (ROC) curves were used to find the optimal cut-off for P msa to indicate fluid responsiveness. Changes in blood volume were estimated from anthropometric data and the haemodilution.
resultsPmsa was lower in fluid responders than in non-responders before induction (13.2 ± 2.2 vs. 14.7 ± 2.7 mmHg; mean ± SD, P < 0.01) and after induction of general anaesthesia (11.4 ± 2.1 vs. 12.8 ± 2.1 mmHg; P < 0.006). ROC curves showed that 14 mmHg before anaesthesia and 12 mmHg after anaesthesia induction served as optimal cut-offs for P msa to indicate fluid responsiveness. A linear correlation between P msa and blood volume changes suggested that the anaesthesia increased the unstressed blood volume by 1.2 L.
conclusionsP msa was lower in fluid responders than in non-responders. General anaesthesia increased the need for blood volume by 1.2 L.
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