Evidence map›Paper›PMID 36734357›Full record

ReviewThe journals of gerontology. Series B, Psychological sciences and social sciences2023

Well-Being as a Protective Factor Against Cognitive Decline and Dementia: A Review of the Literature and Directions for Future Research.

Emily C Willroth, Gabrielle N Pfund, Chloe McGhee, Payton Rule

Abstract readReview
In one paragraph

Review in The journals of gerontology. Series B, Psychological sciences and social sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Wellbeing trajectories and dementia risk among Mexican-origin adults living in the U.S.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
  2. Do all components of psychological well-being predict cognitive function?The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  3. Article
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  6. Investigating the trivariate reciprocal longitudinal relationships between purpose, loneliness, and cognitive function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  7. Article
  8. Optimism and cognitive functioning trajectories in a cohort of aging men.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
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  11. Observational
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  14. Prosocial Intentions and Subsequent Cognitive Health: A Prospective Cohort Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emily C WillrothDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.
Gabrielle N PfundDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Chloe McGheePsychiatry & Behavioral Sciences, Stanford School of Medicine, Stanford, California, USA.
Payton RuleDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.

Funding

Well-being as a Protective Factor against Cognitive Decline and Dementia RiskR00AG071838 · NIA · WASHINGTON UNIVERSITY · PI WILLROTH, EMILY C · 2022 to 2024
$853k
NIA NIH HHS R00 AG071838
6 · The paper itself

Abstract

objectivesTreatments that target the biological causes of dementia remain limited, making prevention critically important. Well-being-defined broadly as living in accordance with one's potential and experiencing one's life as enjoyable and satisfying-is a promising avenue for prevention. It can be targeted by large-scale, noninvasive interventions and has been linked with better cognitive health and lower dementia risk. In the current review, we begin by summarizing empirical evidence linking well-being to cognitive functioning, cognitive decline, dementia diagnosis, and dementia-related neuropathology. Then, we highlight 3 key areas for future research.

methodsWe searched the literature on wellbeing, cognitive decline, and dementia, focusing on prospective and longitidinal evidence.

resultsThe research reviewed here provides consistent evidence for associations of well-being with cognitive decline, dementia risk, and cognitive resilience to neuropathology. However, several open questions remain regarding (1) causality and mechanism(s), (2) specificity versus generalizability of associations, and (3) timing. DISCUSSION: To inform potential intervention efforts, the field must address complex open questions about whether, how, when, and for whom well-being influences dementia risk. The majority of existing research on well-being and cognitive health is correlational, and few studies have tested potential mechanisms that may explain those associations. Further, relatively little is known about the generalizability of associations across different aspects of well-being and for different sociocultural groups. Finally, we do not yet understand when in the life span and on what timescale well-being might influence cognitive health. We discuss challenges and opportunities for addressing each of these open questions, including concrete recommendations for research designs and use of open science practices.

Indexed as

Cognitive DysfunctionDementiaCognitionHumansProspective StudiesProtective FactorsCognitive agingLife satisfactionPurposeReview paper

Identifiers

PMID36734357
PMCPMC10174196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.