Evidence map›Paper›PMID 36734304›Full record

ArticleCancer medicine2023

Validity of pathological diagnosis for early colorectal cancer in genetic background.

Kenichiro Okimoto, Yosuke Hirotsu, Makoto Arai, Kenji Amemiya, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Hiroshi Ohyama, Tomoaki Matsumura and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Kenichiro OkimotoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-5809-1254
Yosuke HirotsuGenome Analysis Center, Yamanashi Prefectural Central Hospital, Kofu, Japan.ORCID 0000-0002-8002-834X
Makoto AraiDepartment of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
Kenji AmemiyaGenome Analysis Center, Yamanashi Prefectural Central Hospital, Kofu, Japan.ORCID 0000-0003-4223-0528
Naoki AkizueDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yuki OhtaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Takashi TaidaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Keiko SaitoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hiroshi OhyamaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Tomoaki MatsumuraDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Motoi NishimuraDivision of Clinical Genetics and Proteomics, Department of Laboratory Medicine, Chiba University Hospital, Chiba, Japan.
Kazuyuki MatsushitaDivision of Clinical Genetics and Proteomics, Department of Laboratory Medicine, Chiba University Hospital, Chiba, Japan.ORCID 0000-0001-6742-0761
Keisuke MatsusakaDepartment of Molecular Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Toshio OyamaDepartment of Pathology, Yamanashi Central Hospital, Kofu, Japan.
Hitoshi MochizukiGenome Analysis Center, Yamanashi Prefectural Central Hospital, Kofu, Japan.
Tetsuhiro ChibaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0001-7179-0765
Jun KatoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Jun-Ichiro IkedaDepartment of Molecular Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Osamu YokosukaChiba University, Chiba, Japan.
Naoya KatoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masao OmataGenome Analysis Center, Yamanashi Prefectural Central Hospital, Kofu, Japan.
Chiba University · JPYamanashi Prefectural Central Hospital · JPChiba University Hospital · JPTokyo Women's Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate the validity of pathological diagnosis of early CRC (E-CRC) from the genetic background by comparing data of E-CRC to colorectal adenoma (CRA) and The Cancer Genome Atlas (TCGA) on advanced CRC (AD-CRC).

methodsTCGA data on AD-CRC were studied in silico, whereas by next-generation sequencer, DNA target sequences were performed for endoscopically obtained CRA and E-CRC samples. Immunohistochemical staining of mismatch repair genes and methylation of MLH1 was also performed. The presence of oncogenic mutation according to OncoKB for the genes of the Wnt, MAPK, and cell-cycle-signaling pathways was compared among CRA, E-CRC, and AD-CRC.

resultsThe study included 22 CRA and 30 E-CRC lesions from the Chiba University Hospital and 212 AD-CRC lesions from TCGA data. Regarding the number of lesions with driver mutations in the Wnt and cell-cycle-signaling pathways, E-CRC was comparable to AD-CRC, but was significantly greater than CRA. CRA had significantly more lesions with a driver mutation for the Wnt signaling pathway only, versus E-CRC.

conclusionsIn conclusion, the definition of E-CRC according to the Japanese criteria had a different genetic profile from CRA and was more similar to AD-CRC. Based on the main pathway, it seemed reasonable to classify E-CRC as adenocarcinoma. The pathological diagnosis of E-CRC according to Japanese definition seemed to be valid from a genetic point of view.

Indexed as

AdenocarcinomaColorectal NeoplasmsGenetic BackgroundHumanscolorectal adenomacolorectal cancernext-generation sequencepathological diagnosisTCGA

Identifiers

PMID36734304
PMCPMC10134368
OpenAlexW4319062325

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.