Evidence map›Paper›PMID 36734246›Full record

ArticleThe Journal of international medical research2023

DNA methylation status of interspersed repetitive sequences in patients with migraine.

Nino Kraveishvili, Eka Kvaratskhelia, Sandro Surmava, Merab Kvintradze, Maia Zarandia, Tinatin Gorgiladze, Elene Abzianidze

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Article in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nino KraveishviliDepartment of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia.
Eka KvaratskheliaDepartment of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia.ORCID 0000-0002-1200-0230
Sandro SurmavaDepartment of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia.
Merab KvintradzeDepartment of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia.
Maia ZarandiaDepartment of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia.
Tinatin GorgiladzeDepartment of Dentistry, Batumi Shota Rustaveli State University, Batumi, Georgia.
Elene AbzianidzeDepartment of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyse the methylation status of the Long Interspersed Nuclear Element-1 (LINE-1) and Short Interspersed Nuclear Element Alu (Alu) of peripheral blood mononuclear cells (PBMCs) from patients with migraine compared with healthy control subjects.

methodsThis case-control study recruited patients with migraine without aura and age-matched healthy control subjects. PBMCs were purified from peripheral blood samples. Methylation levels and patterns of LINE-1 and Alu sequences were evaluated using combined bisulfite restriction analysis-interspersed repetitive sequences polymerase chain reaction.

resultsA total of 84 patients with migraine and 82 age-matched healthy controls were enrolled in the study. High levels of unmethylated cytosines in both the LINE-1 and Alu repetitive elements were observed in the migraine group compared with the control subjects. In addition, a significant difference was detected in the methylation level of LINE-1 between TT and CC genotype groups of the methylenetetrahydrofolate reductase gene.

conclusionsThese results suggest that analysis of epigenetic biomarkers in PBMCs may help to identify patients at a higher risk of migraine development.

Indexed as

DNA MethylationInterspersed Repetitive SequencesLong Interspersed Nucleotide ElementsMigraine DisordersAlu ElementsCase-Control StudiesHumansLeukocytes, MononuclearAluDNA methylationinterspersed repetitive sequencesLINE-1Long Interspersed Nuclear ElementmigraineShort Interspersed Nuclear Element

Identifiers

PMID36734246
PMCPMC9900668

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