ArticleAging cell2023
Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy.
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Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20citing papers in PubMed, 1 pooled it
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Viral Myocarditis as a Factor Leading to the Development of Heart Failure Symptoms, Including the Role of Parvovirus B19 Infection-Systematic Review.International journal of molecular sciences · 2024Pooled it
- From aging biology to cardiac biotechnology: emerging platforms for modeling cardiac aging.JCI insight · 2026Review
- Senescence dynamics define therapeutic windows for Duchenne muscular dystrophy in DBA/2-mdx mice.Skeletal muscle · 2026Article
- DNA damage and repair in cardiomyopathy: mechanisms and therapeutic opportunities.American journal of physiology. Heart and circulatory physiology · 2026Review
- Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases: A Review of Recent Advances and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Unraveling the intersection of aging and Parkinson's disease: a collaborative roadmap for advancing research models.NPJ Parkinson's disease · 2026Review
- The Pathogenic Role of the DNA Double-Stranded Breaks in Hereditary Cardiomyopathies.Heart failure clinics · 2026Review
- DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopathy.Cardiovascular research · 2025Article
- Obesity accelerates cardiovascular ageing.European heart journal · 2025Review
- Causes and consequences of DNA double-stranded breaks in cardiovascular disease.Molecular and cellular biochemistry · 2025Review
- Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction.Cell death & disease · 2025Article
- Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway.Frontiers in pharmacology · 2025Article
- Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy.Theranostics · 2025Article
- Mitochondria associated membranes in dilated cardiomyopathy: connecting pathogenesis and cellular dysfunction.Frontiers in cardiovascular medicine · 2025Review
- PGAM5 interacts with and maintains BNIP3 to license cancer-associated muscle wasting.Autophagy · 2024Article
- Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice.Molecular imaging and biology · 2024Article
- Replication-Independent ICL Repair: From Chemotherapy to Cell Homeostasis.Journal of molecular biology · 2024Review
- Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence.Nucleic acids research · 2024Article
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Authors and funding
30 authors at 8 institutions in 1 country.
Chathurika HenpitaDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Rajesh VyasDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Chastity L HealyDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA.
Tra L KieuDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Aditi U GurkarDepartment of Molecular Medicine, Scripps Research Institute, Jupiter, Florida, USA.
Matthew J YousefzadehDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Yuxiang CuiDepartment of Chemistry, University of California, Riverside, Riverside, California, USA.
Aiping LuDepartment of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Luise A AngeliniDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Ryan D O'KellyDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Sara J McGowanDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Sanjay ChandrasekharDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Rebecca R VanderpoolDivision of Cardiology, Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Danielle Hennessy-WackDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Mark A RossCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Timothy N BachmanDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Charles McTiernanDivision of Cardiology, Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Smitha P S PillaiFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Warren LadigesDepartment of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Mitra LavasaniDepartment of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Johnny HuardDepartment of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Donna Beer-StolzCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Claudette M St CroixCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Simon C WatkinsCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Paul D RobbinsDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-1068-7099
Ana L MoraDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Eric E KelleyDepartment of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia, USA.
Yinsheng WangDepartment of Chemistry, University of California, Riverside, Riverside, California, USA.ORCID 0000-0001-5565-283X
Timothy D O'ConnellDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA.
Laura J NiedernhoferDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-1074-1385
University of Pittsburgh · USScripps Research Institute · USUniversity of Minnesota · USUniversity of California, Riverside · USFred Hutch Cancer Center · USNorthwestern University · USUniversity of Washington · USWest Virginia University · US
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7MVascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T · 2011 to 2020
$26.1MWest Virginia University Stroke COBREP20GM109098 · NIGMS · WEST VIRGINIA UNIVERSITY · PI HRUSKA, MARTIN · 2014 to 2024
$24.5MPROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2MUsing the senolytic fisetin to suppress mortality in aged mice acutely exposed to murine beta-coronavirusR01AG063543 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2019 to 2023
$3.4MFree fatty acid receptor 4 cardioprotective effects in cardiac ischemic injuryR01HL152215 · NHLBI · UNIVERSITY OF MINNESOTA · PI O'CONNELL, TIMOTHY D, SHEARER, GREGORY C · 2020 to 2024
$3.4MMapping the cell specific DNA damage-induced molecular and bioelectrical responses in the 3D cardiac unitR01HL161106 · NHLBI · CARNEGIE-MELLON UNIVERSITY · PI Tzahi Cohen-Karni, Aditi U Gurkar · 2022 to 2026
$3.1MImproving Aged Neuromuscular Health and FunctionR01AG073223 · NIA · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI Mitra Lavasani · 2022 to 2026
$2.4MEicosapentaenoic acid activation of free fatty acid receptor 4 prevents fibrosis, microvascular rarefaction, and diastolic dysfunction; implications for heart failure preserved ejection fractionR01HL130099 · NHLBI · UNIVERSITY OF MINNESOTA · PI O'CONNELL, TIMOTHY D, SHEARER, GREGORY C · 2016 to 2019
$1.5MPathology of Aging Research NetworkR24AG047115 · NIA · UNIVERSITY OF WASHINGTON · PI LADIGES, WARREN C · 2014 to 2016
$1.1MModulators of DNA damage associated nucleo-mitochondrial communication in agingR00AG049126 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GURKAR, ADITI U · 2017 to 2019
$835kImmune cells as a driver of cell non-autonomous agingR56AG059676 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2018 to 2018
$385kNHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL130099NHLBI NIH HHS R01 HL152215NHLBI NIH HHS R01 HL161106NIA NIH HHS P01 AG043376NIA NIH HHS P01 AG062413NIA NIH HHS R00 AG049126NIA NIH HHS R01 AG063543NIA NIH HHS R01 AG073223NIA NIH HHS R24 AG047115NIA NIH HHS R56 AG059676NIGMS NIH HHS P20 GM109098
Abstract
Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. Genotoxic cancer therapies are known to be potent drivers of cardiomyopathy, whereas causes of spontaneous disease remain unclear. To test the hypothesis that endogenous genotoxic stress contributes to cardiomyopathy, we deleted the DNA repair gene Ercc1 specifically in striated muscle using a floxed allele of Ercc1 and mice expressing Cre under control of the muscle-specific creatinine kinase (Ckmm) promoter or depleted systemically (Ercc1
Indexed as
Cardiomyopathy, DilatedMyocytes, CardiacAnimalsDNA RepairMiceMyocardiumTumor Suppressor Protein p53Tumor Suppressor Protein p53cardiomyopathycongestive heart failuregenotoxic stressoxidative stress
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.