Evidence map›Paper›PMID 36733851›Full record

ReviewFrontiers in cellular and infection microbiology2022

Tools to develop antibiotic combinations that target drug tolerance in

Talia Greenstein, Bree B Aldridge

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Metabolic perturbation reduces antibiotic tolerance inMicrobiology (Reading, England) · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. REVOLUTIONIZING TUBERCULOSIS REGIMEN DEVELOPMENT.Transactions of the American Clinical and Climatological Association · 2025
    Review
  10. Review
  11. Characterizing the immune response toFrontiers in immunology · 2024
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Talia GreensteinDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, United States.
Bree B AldridgeDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, United States.
Tufts University · US

Funding

Lesion-centric optimization of multidrug therapies for tuberculosisR01AI150684 · NIAID · TUFTS UNIVERSITY BOSTON · PI ALDRIDGE, BREE BEARDSLEY, KIRSCHNER, DENISE E · 2020 to 2024
$4.2M
Gates Foundation INV-027276NIAID NIH HHS R01 AI150684
6 · The paper itself

Abstract

Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed. The adaptation of

Indexed as

Mycobacterium tuberculosisTuberculosisAntitubercular AgentsDrug Therapy, CombinationDrug ToleranceHumansLeprostatic AgentsAntitubercular AgentsLeprostatic Agentsdormancydrug combinationsdrug interactiondrug tolerancepharmacodynamics (PD)pharmacokinetics (PK)tuberculosis

Identifiers

PMID36733851
PMCPMC9888313
OpenAlexW4313649525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.