ArticleBiomedical optics express2022
Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Next-gen vision: a systematic review on robotics transforming ophthalmic surgery.Journal of robotic surgery · 2025Pooled it
- Cumulative Loss of Inner Retinal Neurons in Healthy and Glaucoma Subjects.Investigative ophthalmology & visual science · 2026Article
- Reflective broadband adaptive optics scanning light ophthalmoscope with 20 D focus range.Biomedical optics express · 2026Article
- Toward Organelle Motility as a Functional Biomarker of Retinal Pigment Epithelium Health.Translational vision science & technology · 2026Article
- Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable.Biomedical optics express · 2026Article
- Circumferential multi-contrast mapping of the aqueous outflow pathway in human eyes facilitated by circular-scan optical coherence tomography angiography.Biomedical optics express · 2026Article
- Article
- Computational aberration correction enables full-thickness retinal imaging with adaptive optics optical coherence tomography.Biocybernetics and biomedical engineering · 2026Article
- Surpassing the diffraction limit for improved lateral resolution in adaptive optics optical coherence tomography of the living human eye.Communications engineering · 2025Article
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- Integrated fixation and stimulus channel for adaptive optics ophthalmoscopy.Biomedical optics express · 2025Article
- Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025Article
- Non-mydriatic handheld optical coherence tomography for panretinal imaging.Biomedical optics express · 2025Article
- Wide-field choriocapillaris mapping with 3.4 MHz adaptive optics-optical coherence tomography angiography.Biomedical optics express · 2025Article
- Combined optical coherence tomography and electroretinography system for imaging neurovascular coupling in the human retina.Neurophotonics · 2025Article
- Telecentric model eye for correction of image distortion in adaptive optics ophthalmoscopes.Biomedical optics express · 2025Article
- Artificial intelligence-assisted retinal imaging enables dense pixel sampling from sparse measurements.NPJ artificial intelligence · 2025Article
- Identifying retinal pigment epithelium cells in adaptive optics-optical coherence tomography images with partial annotations and superhuman accuracy.Biomedical optics express · 2024Article
- Ultrafast adaptive optics for imaging the living human eye.Nature communications · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the design and performance of a multimodal and multifunctional adaptive optics (AO) system that combines scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) for simultaneous retinal imaging at 13.4 Hz. The high-speed AO-OCT channel uses a 3.4 MHz Fourier-domain mode-locked (FDML) swept source. The system achieves exquisite resolution and sensitivity for pan-macular and transretinal visualization of retinal cells and structures while providing a functional assessment of the cone photoreceptors. The ultra-high speed also enables wide-field scans for clinical usability and angiography for vascular visualization. The FDA FDML-AO system is a powerful platform for studying various retinal and neurological diseases for vision science research, retina physiology investigation, and biomarker development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.