Evidence map›Paper›PMID 36733740›Full record

ArticleBiomedical optics express2022

Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy.

Rajib Dey, Sergey Alexandrov, Peter Owens, Jack Kelly, Sine Phelan, Martin Leahy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Cutaneous Oncology: Strategies for Melanoma Prevention, Diagnosis, and Therapy.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rajib DeyTissue Optics and Microcirculation Imaging (TOMI) Facility, National Biophotonics and Imaging Platform School of Physics, National University of Ireland, Galway, Galway, Ireland.ORCID https://orcid.org/0000-0002-4701-3939
Sergey AlexandrovTissue Optics and Microcirculation Imaging (TOMI) Facility, National Biophotonics and Imaging Platform School of Physics, National University of Ireland, Galway, Galway, Ireland.ORCID https://orcid.org/0000-0001-5232-5868
Peter OwensCenter for Microscopy and Imaging, National University of Ireland, Galway, Galway, Ireland.
Jack KellyPlastic and Reconstructive Surgery, Galway University Hospital, Galway, Ireland.
Sine PhelanDepartment of Anatomic Pathology, Galway University Hospital and Department of Pathology, National University of Ireland, Galway, Galway, Ireland.
Martin LeahyTissue Optics and Microcirculation Imaging (TOMI) Facility, National Biophotonics and Imaging Platform School of Physics, National University of Ireland, Galway, Galway, Ireland.ORCID https://orcid.org/0000-0003-1558-4574
Ollscoil na Gaillimhe – University of Galway · IEInstitute of Photonic Sciences · ESUniversity Hospital Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excision biopsy and histology represent the gold standard for morphological investigation of the skin, in particular for cancer diagnostics. Nevertheless, a biopsy may alter the original morphology, usually requires several weeks for results, is non-repeatable on the same site and always requires an iatrogenic trauma. Hence, diagnosis and clinical management of diseases may be substantially improved by new non-invasive imaging techniques. Optical Coherence Tomography (OCT) is a non-invasive depth-resolved optical imaging modality based on low coherence interferometry that enables high-resolution, cross-sectional imaging in biological tissues and it can be used to obtain both structural and functional information. Beyond the resolution limit, it is not possible to detect structural and functional information using conventional OCT. In this paper, we present a recently developed technique, nanosensitive OCT (nsOCT), improved using broadband supercontinuum laser, and demonstrate nanoscale sensitivity to structural changes within

Identifiers

PMID36733740
PMCPMC9872867
OpenAlexW4301397588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.