Evidence map›Paper›PMID 36733393›Full record

ArticleFrontiers in immunology2022

A multi-epitope vaccine GILE against

Pei Zhou, Zhen Zhou, Meiduo Huayu, Lei Wang, Lin Feng, Yang Xiao, Yao Dai, Mingyuan Xin, Feng Tang, Runle Li

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Characterization of 2-deoxyribose-5-phosphate aldolase from Bacillus altitudinis JYY-02.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
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  9. Evaluation of a multi-epitope vaccine PME forFrontiers in immunology · 2025
    Article
  10. Article
  11. Current status and future prospects ofVeterinary and animal science · 2024
    Review
  12. Immunoprotective effect and mechanism of rEg.P29 against CD4Acta biochimica et biophysica Sinica · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pei ZhouQinghai University Medical College, Xining, Qinghai, China.
Zhen ZhouResearch Center for High Altitude Medicine, Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Qinghai Provincial Key Laboratory of Plateau Medical Application, Key Laboratory of Ministry of Education, Qinghai University, Xining, Qinghai, China.
Meiduo HuayuResearch Center for High Altitude Medicine, Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Qinghai Provincial Key Laboratory of Plateau Medical Application, Key Laboratory of Ministry of Education, Qinghai University, Xining, Qinghai, China.
Lei WangDepartment of Pathology, The Second Xiangya Hospital DE Central South University, Changsha, Hunan, China.
Lin FengQinghai University Medical College, Xining, Qinghai, China.
Yang XiaoQinghai University Medical College, Xining, Qinghai, China.
Yao DaiQinghai University Medical College, Xining, Qinghai, China.
Mingyuan XinQinghai University Medical College, Xining, Qinghai, China.
Feng TangResearch Center for High Altitude Medicine, Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Qinghai Provincial Key Laboratory of Plateau Medical Application, Key Laboratory of Ministry of Education, Qinghai University, Xining, Qinghai, China.
Runle LiQinghai University Medical College, Xining, Qinghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The objective of this study is to construct a multi-epitope vaccine GILE containing B-cell and T-cell epitopes against Methods: The structure and hydrophobicity of GILE were predicted by SWISSMODEL, pyMOL, SOPMA and VMD, and its sequence was optimized by Optimum™ Codon. The GILE gene was inserted into pCzn1 and transformed into Results: The SWISS-MODEL analysis showed that the optimal model was EMY162 Discussion: A multi-epitope vaccine GILE with good immunogenicity and antigenicity has been successfully constructed in this study, which may provide important theoretical and experimental bases for the prevention and treatment of

Indexed as

Interleukin-4VaccinesAnimalsEchinococcosisEpitopes, T-LymphocyteInterferon-gammaMiceRecombinant ProteinsEpitopes, T-LymphocyteInterferon-gammaInterleukin-4Recombinant ProteinsVaccinesbioinformaticsEchinococcus multilocularisimmunemulti-epitope vaccineprokaryotic expression

Identifiers

PMID36733393
PMCPMC9887108

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.