Evidence map›Paper›PMID 36732855›Full record

ArticleInternational journal of retina and vitreous2023

Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases.

Kayla M White, Itamar Livnat, Caroline R Frambach, John Doan, Urmi V Mehta, Clara Yuh, Anton M Palma, Kimberly A Jameson, M Cristina Kenney, Mitul C Mehta and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of retina and vitreous, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kayla M WhiteSchool of Medicine, University of California, Irvine, CA, 92617, USA.
Itamar LivnatDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, 92617, USA. ilivnat@hs.uci.edu.ORCID http://orcid.org/0000-0002-6390-7473
Caroline R FrambachSchool of Medicine, University of California, Irvine, CA, 92617, USA.
John DoanMedical College of Wisconsin, Wauwatosa, WI, 53226, USA.
Urmi V MehtaDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, 92617, USA.
Clara YuhUniversity of California, Irvine, CA, 92617, USA.
Anton M PalmaInstitute for Clinical and Translational Sciences University, Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA, 92617, USA.
Kimberly A JamesonInstitute for Mathematical Behavioral Sciences, University of California, Irvine, CA, 92617, USA.
M Cristina KenneyDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, 92617, USA.
Mitul C MehtaDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, 92617, USA.
Chantal J BoisvertDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, 92617, USA.
Wade R CrowDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, 92617, USA.
Andrew W BrowneDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, 92617, USA.
University of California, Irvine · USDuke University · USMedical College of Wisconsin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCone contrast threshold testing (CCT) provides quantitative measurements of color and contrast function to reveal changes in vision quality that are not standard endpoints in clinical trials. We utilize CCT to measure visual function in patients with multiple sclerosis (MS), age-related macular degeneration (AMD), epiretinal membrane (ERM), and retinal vein occlusion (RVO).

methodsRetrospective data was gathered from 237 patients of the Gavin Herbert Eye Institute. Subjects included 17 patients with MS, 45 patients with AMD, 41 patients with ERM, 11 patients with RVO, and 123 healthy controls. Patients underwent the primary measurement outcome, CCT testing, as well as Sloan visual acuity test and spectral domain optical coherence tomography during normal care.

resultsColor and contrast deficits were present in MS patients regardless of history of optic neuritis. AMD with intermediate or worse disease demonstrated reduced CCT scores. All 3 stages of ERM demonstrated cone contrast deficits. Despite restoration of visual acuity, RVO-affected eyes demonstrated poorer CCT performance than unaffected fellow eyes.

conclusionsCCT demonstrates color and contrast deficits for multiple retinal diseases with differing pathophysiology. Further prospective studies of CCT in other disease states and with larger samples sizes is warranted.

Indexed as

Age-related macular degenerationColor visionCone contrast threshold testing (CCT)Epiretinal membraneMultiple sclerosisOptic neuritisRetinal vein occlusion

Identifiers

PMID36732855
PMCPMC9893567
OpenAlexW4319020216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.