SynthesisCritical care (London, England)2023
Does tidal volume challenge improve the feasibility of pulse pressure variation in patients mechanically ventilated at low tidal volumes? A systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06123039 (Use of Heart-lung Interaction Parameters to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP During Invasive Mechanical Ventilation in the Operating Room), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Heart-lung Interaction Parameters to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP During Invasive Mechanical Ventilation in the Operating Room
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- Changes in pulse pressure variation induced by passive leg raising test to predict preload responsiveness in mechanically ventilated patients with low tidal volume in ICU: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Variables influencing the prediction of fluid responsiveness: a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- Respiratory variation in the internal jugular vein does not predict fluid responsiveness in the prone position during adolescent idiopathic scoliosis surgery: a prospective cohort study.BMC anesthesiology · 2023Trial
- Respiratory variation in carotid artery blood flow peak velocity combined with tidal volume challenge in predicting fluid responsiveness of lung-protective ventilation patients: a feasibility study.Journal of clinical monitoring and computing · 2026Article
- Key strategies in trauma anesthesia for severe hemorrhage: a narrative review.Korean journal of anesthesiology · 2026Review
- Variation of perfusion index to evaluate fluid responsiveness during the preload challenge tests: a systematic review and meta-analysis.Annals of intensive care · 2026Article
- The time course of fluid responsiveness.Annals of intensive care · 2026Review
- Applied physiology at the bedside: using invasive blood pressure as a true monitoring tool.Annals of intensive care · 2025Review
- Changes in internal jugular vein respiratory variation during tidal volume challenge predict volume responsiveness in lumbar surgery under protective ventilation: a prospective cohort study.Journal of intensive care · 2025Article
- The role of the tidal volume challenge test in volume responsiveness assessment: a narrative review.Journal of anesthesia, analgesia and critical care · 2025Review
- SIGHCritical care (London, England) · 2025Article
- Improved Prediction of Fluid Responsiveness in Ventilated Patients With Low Tidal Volume: The Role of Preload Variation.Critical care explorations · 2025Article
- Using the ventilator to predict fluid responsiveness.Intensive care medicine · 2025Article
- Changes in central venous-to-arterial PCOCritical care (London, England) · 2024Article
- Assessment of fluid responsiveness after tidal volume challenge in renal transplant recipients: a nonrandomized prospective interventional study.Clinical transplantation and research · 2024Article
- Testing preload responsiveness by the tidal volume challenge assessed by the photoplethysmographic perfusion index.Critical care (London, England) · 2024Article
- Optimization of kidney function in cardiac surgery patients with intra-abdominal hypertension: expert opinion.Perioperative medicine (London, England) · 2024Review
- Recent advances in cardiorespiratory monitoring in acute respiratory distress syndrome patients.Journal of intensive care · 2024Review
- Measurement error of pulse pressure variation.Journal of clinical monitoring and computing · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulse pressure variation (PPV) has been widely used in hemodynamic assessment. Nevertheless, PPV is limited in low tidal volume ventilation. We conducted this systematic review and meta-analysis to evaluate whether the tidal volume challenge (TVC) could improve the feasibility of PPV in patients ventilated at low tidal volumes.
methodsPubMed, Embase and Cochrane Library inception to October 2022 were screened for diagnostic researches relevant to the predictability of PPV change after TVC in low tidal volume ventilatory patients. Summary receiving operating characteristic curve (SROC), pooled sensitivity and specificity were calculated. Subgroup analyses were conducted for possible influential factors of TVC.
resultsTen studies with a total of 429 patients and 457 measurements were included for analysis. The predictive performance of PPV was significantly lower than PPV change after TVC in low tidal volume, with mean area under the receiving operating characteristic curve (AUROC) of 0.69 ± 0.13 versus 0.89 ± 0.10. The SROC of PPV change yielded an area under the curve of 0.96 (95% CI 0.94, 0.97), with overall pooled sensitivity and specificity of 0.92 (95% CI 0.83, 0.96) and 0.88 (95% CI 0.76, 0.94). Mean and median cutoff value of the absolute change of PPV (△PPV) were 2.4% and 2%, and that of the percentage change of PPV (△PPV%) were 25% and 22.5%. SROC of PPV change in ICU group, supine or semi-recumbent position group, lung compliance less than 30 cm H
conclusionsTVC is capable to help PPV overcome limitations in low tidal volume ventilation, wherever in ICU or surgery. The accuracy of TVC is not influenced by reduced lung compliance, moderate PEEP and measurement tools, but TVC should be cautious applied in prone position and patients with spontaneous breathing activity. Trial registration PROSPERO (CRD42022368496). Registered on 30 October 2022.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.