Evidence map›Paper›PMID 36732808›Full record

ArticleTrials2023

Lateral compression type 1 fracture fixation in the elderly (L1FE): study protocol for a randomised controlled trial (with internal pilot) comparing the effects of INFIX surgery and non-surgical management for treating patients with lateral compression type 1 (LC-1) fragility fractures.

Elizabeth Cook, Joanne Laycock, Mehool Acharya, Michael Ross Backhouse, Belen Corbacho, Laura Doherty, Daren Forward, Catherine Hewitt, Catherine Hilton, Peter Hull and 7 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Operative care rates of lateral compression type 1 pelvic fractures increased from 2003 to 2018.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Elizabeth CookYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK. liz.cook@york.ac.uk.ORCID http://orcid.org/0000-0001-6902-0235
Joanne LaycockYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Mehool AcharyaPelvic and Acetabular Reconstruction Unit, Southmead Hospital, Bristol, BS10 5NB, UK.
Michael Ross BackhouseYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Belen CorbachoYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Laura DohertyYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Daren ForwardNottingham University Hospitals, Derby Road, Nottingham, NG7 2UH, UK.
Catherine HewittYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Catherine HiltonBart's Health NHS Trust, The Royal London Hospital, Whitechapel Road, Whitechapel, London, E1 1BB, UK.
Peter HullCambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK.
Jamila KassamBart's Health NHS Trust, The Royal London Hospital, Whitechapel Road, Whitechapel, London, E1 1BB, UK.
Camila MaturanaYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Catriona McdaidYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Jenny RocheYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Dhanupriya SivapathasuntharamBart's Health NHS Trust, The Royal London Hospital, Whitechapel Road, Whitechapel, London, E1 1BB, UK.
David TorgersonYork Trials Unit, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK.
Peter BatesBart's Health NHS Trust, The Royal London Hospital, Whitechapel Road, Whitechapel, London, E1 1BB, UK.
University of York · GBBarts Health NHS Trust · GBCambridge University Hospitals NHS Foundation Trust · GBNottingham University Hospitals NHS Trust · GBSouthmead Hospital · GBUniversity of Warwick · GB

Funding

Health Technology Assessment Programme 16/167/57
6 · The paper itself

Abstract

backgroundLateral compression type1 (LC-1) fragility fractures are a common, painful injury in older adults resulting in reduced mobility. The incidence of these fractures is increasing with the growing older adult population. The current standard of care is non-surgical management; however, patients with this injury are at risk of long-term immobility and related complications. INFIX is a pelvic fixation device used in younger patients with high-energy fractures. The device is fitted via a percutaneous technique with no external pin sites and has good purchase even in osteoporotic bone. It therefore has the potential to be well tolerated in patients with LC-1 fragility fractures. INFIX could improve patients' ability to mobilise and reduce the risk of immobility-related complications. However, there is a risk of complications related to surgery, and robust evidence is required on patient outcomes. This study will investigate the clinical and cost-effectiveness of surgical fixation with INFIX compared to non-surgical management of LC-1 fragility fractures in older adults.

methodsA multi-centre randomised controlled trial of 600 patients allocated 1:1 to non-surgical management or INFIX surgery. The study will have a 12-month internal pilot to assess recruitment and trial feasibility. The primary outcome will be the patient quality of life over 6 months, measured by the patient-reported EQ-5D-5L. The secondary outcomes will include physical function, mental health, pain, delirium, imaging assessment, resource use, and complications. DISCUSSION: The L1FE study aims to compare the clinical and cost-effectiveness of surgical and non-surgical management of people aged 60 years and older with LC-1 fragility fractures. The trial is sufficiently powered and rigorously designed to inform future clinical and patient decision-making and allocation of NHS resources.

trial registrationInternational Standard Randomised Controlled Trial Number Registry ISRCTN16478561. Registered on 8 April 2019.

Indexed as

Fractures, BoneQuality of LifeAgedBone PlatesFracture FixationFracture Fixation, InternalHumansMiddle AgedMulticenter Studies as TopicRandomized Controlled Trials as TopicElderly patientsFragility fractureImmobility-related complicationsINFIX surgeryLateral compression type 1LC-1Older adultsOsteoporotic bonePelvic fracture fixationPubic ramus fracture

Identifiers

PMID36732808
PMCPMC9893645
OpenAlexW4319002804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.