ArticleRespiratory research2023
Vascular and pulmonary effects of ibuprofen on neonatal lung development.
Article in Respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Beneficial vs harmful effects of pharmacological treatment of patent ductus arteriosus: A Bayesian meta-analysis.Pediatric research · 2025Pooled it
- Does use of acetaminophen and/or NSAIDs increase the risk of developing bronchopulmonary dysplasia?Pediatric research · 2026Article
- AI, machine learning, and adjudication of hemodynamically significant PDA in extremely premature infants.Pediatric research · 2026Article
- Synthesis of activated carbons and nanoparticle-loaded activated carbons derived from bio-wastes for the removal of ibuprofen drug from water.Nanoscale advances · 2026Review
- Umbilical cord blood platelet lysate preserves myofibroblast migration and mitigates hyperoxic lung injury.Pediatric research · 2026Article
- The association between patent ductus arteriosus and adverse outcomes in preterm infants.BMC pediatrics · 2026Article
- PDA in Prematurity: Rethinking a Decades-Old Debate in 2026.Biomedicines · 2026Review
- Association of patent ductus arteriosus duration with bronchopulmonary dysplasia and mortality: a cohort study.Pediatric research · 2025Article
- Pulmonary Hemorrhage in Premature Infants: Pathophysiology, Risk Factors and Clinical Management.Biomedicines · 2025Review
- Predictive model of ibuprofen treatment failure in very preterm infants with patent ductus arteriosus using machine learning techniques.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Research progress of microvascular development in bronchopulmonary dysplasia.Pediatric investigation · 2024Review
- The standardization and efficacy of fermentedOpen veterinary journal · 2024Article
- Association of Fetal Lung Development Disorders with Adult Diseases: A Comprehensive Review.Journal of personalized medicine · 2024Review
- Evaluation of the association between patent ductus arteriosus approach and neurodevelopment in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundIbuprofen is a nonsteroidal anti-inflammatory drug that is commonly used to stimulate closure of a patent ductus arteriosus (PDA) in very premature infants and may lead to aberrant neonatal lung development and bronchopulmonary dysplasia (BPD).
methodsWe investigated the effect of ibuprofen on angiogenesis in human umbilical cord vein endothelial cells (HUVECs) and the therapeutic potential of daily treatment with 50 mg/kg of ibuprofen injected subcutaneously in neonatal Wistar rat pups with severe hyperoxia-induced experimental BPD. Parameters investigated included growth, survival, lung histopathology and mRNA expression.
resultsIbuprofen inhibited angiogenesis in HUVECs, as shown by reduced tube formation, migration and cell proliferation via inhibition of the cell cycle S-phase and promotion of apoptosis. Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.
conclusionsIn conclusion, ibuprofen has dual effects on lung development: adverse effects on angiogenesis and beneficial effects on alveolarization and inflammation. Therefore, extrapolation of the beneficial effects of ibuprofen to premature infants with BPD should be done with extreme caution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.