ArticleNature neuroscience2023
Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their 'readout' of visual input.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Functional organization of dendritic spines in mouse visual cortex layer 2/3 neurons.iScience · 2026Article
- Concordant transcriptional and morphological remodeling revealed bybioRxiv : the preprint server for biology · 2026Article
- CBLN2 promoter enables genetic access to wide-field neurons of the tree shrew superior colliculus.Cell reports methods · 2026Article
- Circuit-level dynamics and propagation of slow wave activity modulate their interplay during the awakening process.iScience · 2025Article
- Coordination of distinct sources of excitatory inputs enhances motion selectivity in the mouse visual thalamus.Neuron · 2025Article
- Biologically grounded neocortex computational primitives implemented on neuromorphic hardware improve vision transformer performance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Combining nanobody labeling with STED microscopy reveals input-specific and layer-specific organization of neocortical synapses.PLoS biology · 2025Article
- Biophysical and computational insights from modeling human cortical pyramidal neurons.Frontiers in neuroscience · 2025Review
- Instability of excitatory synapses in experimental autoimmune encephalomyelitis and the outcome for excitatory circuit inputs to individual cortical neurons.Brain, behavior, and immunity · 2024Article
- Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Current Best Practices for Analysis of Dendritic Spine Morphology and Number in Neurodevelopmental Disorder Research.ACS chemical neuroscience · 2023Review
- Delving into thalamic drive.Nature reviews. Neuroscience · 2023Article
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Authors and funding
9 authors at 7 institutions in 4 countries.
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Abstract
The thalamus is the main gateway for sensory information from the periphery to the mammalian cerebral cortex. A major conundrum has been the discrepancy between the thalamus's central role as the primary feedforward projection system into the neocortex and the sparseness of thalamocortical synapses. Here we use new methods, combining genetic tools and scalable tissue expansion microscopy for whole-cell synaptic mapping, revealing the number, density and size of thalamic versus cortical excitatory synapses onto individual layer 2/3 (L2/3) pyramidal cells (PCs) of the mouse primary visual cortex. We find that thalamic inputs are not only sparse, but remarkably heterogeneous in number and density across individual dendrites and neurons. Most surprising, despite their sparseness, thalamic synapses onto L2/3 PCs are smaller than their cortical counterparts. Incorporating these findings into fine-scale, anatomically faithful biophysical models of L2/3 PCs reveals how individual neurons with sparse and weak thalamocortical synapses, embedded in small heterogeneous neuronal ensembles, may reliably 'read out' visually driven thalamic input.
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