ArticleNature cancer2023
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling.
Open access · greenAbstract read
In one paragraph
Article in Nature cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
32.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 135 citations in OpenAlex.
- Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.Genes & diseases · 2026Review
- Review
- Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship.Genes & development · 2026Review
- Palmitate promotes liver metastases by decreasing neutrophil antitumour behaviour.Nature metabolism · 2026Article
- CEBPG-Mediated Palmitic Acid Adaptation of Cancer-Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Structure-Activity Relationship of Cycling Molecular Assemblies for Golgi Targeting and Disruption.Journal of medicinal chemistry · 2026Article
- Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis.Cancer discovery · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- CPT1A loss promotes lung metastasis in immune-competent mice via a mechanism of mtDNA release and chronic activation of STING pathway.bioRxiv : the preprint server for biology · 2026Article
- Orchestrating organotropism: miRNA-driven mechanisms of site-specific metastasis in triple-negative breast cancer (Review).Oncology letters · 2026Review
- ACSL5 Mediates Adaptation to the Palmitic Acid-Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis.Cancer research · 2026Article
- Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer.Nature cell biology · 2026Article
- Exosome membrane-biomimetic nanomedicine targets the pre-metastatic nicheMaterials today. Bio · 2026Article
- Astrocytic EAAT1 suppression by EV-ACLY underlies glutamate imbalance and cognitive impairment in POCD.Communications biology · 2026Article
- The pre-metastatic niche: mechanisms, heterogeneity, and therapeutic opportunities.Molecular cancer · 2026Review
- miR-223-3p improves macrophage polarization balance and mitochondrial metabolism to ameliorate uveitis by orchestrating P65Cellular & molecular biology letters · 2026Article
- Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer.APL bioengineering · 2026Article
- CRMP2 inhibits metastasis formation by impairing ILF3-dependent stabilization of CXCL10 mRNA in breast cancer.Cell death & disease · 2026Article
- Obesity is the culprit behind fatty acid-induced inflammation.Nutrition & metabolism · 2026Review
- Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence.Cell death discovery · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
50 authors at 10 institutions in 8 countries.
Patricia Altea-ManzanoLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7075-2051
Ginevra Doglioni *Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-9470-4476
Yawen Liu *Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.
Alejandro M CuadrosLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-5900-5143
Emma NolanThe Francis Crick Institute, London, UK.
Juan Fernández-GarcíaLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3422-3627
Qi WuLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-5901-8438
Mélanie PlanqueLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.
Kathrin Julia LaueDepartment of Human Molecular Genetics & Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Florencia Cidre-AranazHopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.
Xiao-Zheng LiuLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8452-6848
Oskar Marin-BejarLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-6889-6566
Joke Van ElsenLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7349-043X
Ines VermeireLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3366-7410
Dorien BroekaertLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-9777-1607
Sofie DemeyerLaboratory for Molecular Biology of Leukemia, VIB-KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8193-5734
Xander SpotbeenLaboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, Leuven, Belgium.
Jakub IdkowiakLaboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, Leuven, Belgium.
Aurélie MontagneUniversité Paris Cité, NF-kappaB, Différenciation et Cancer, Paris, France.
Margherita DemiccoLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-9396-3281
H Furkan AlkanLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.
Nick RabasThe Francis Crick Institute, London, UK.
Carla Riera-DomingoLaboratory of Tumor Inflammation and Angiogenesis, VIB Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0001-7277-234X
François RichardLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-4353-3619
Tatjana GeukensLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Maxim De SchepperLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Sophia LeducLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Sigrid HatseLaboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-6764-2628
Yentl LambrechtsLaboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-9013-8091
Emily Jane KayCancer Research UK Beatson Institute, Glasgow, UK.
Sergio LillaCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-3142-7640
Alisa AlekseenkoSciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solna, Sweden.ORCID http://orcid.org/0000-0002-4269-4894
Vincent GeldhofLaboratory for Angiogenesis and Vascular Metabolism, VIB-KU Leuven, Leuven, Belgium.
Bram BoeckxLaboratory of Translational Genetics, VIB Center for Cancer Biology, Leuven, Belgium.
Celia de la Calle ArreguiLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4627-2963
Giuseppe FlorisDepartment of Imaging and Pathology, Laboratory of Translational Cell & Tissue Research, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2391-5425
Johannes V SwinnenLaboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7720-5077
Jean-Christophe MarineLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.
Diether LambrechtsLaboratory of Translational Genetics, VIB Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0002-3429-302X
Vicent PelechanoSciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solna, Sweden.ORCID http://orcid.org/0000-0002-9415-788X
Massimiliano MazzoneLaboratory of Tumor Inflammation and Angiogenesis, VIB Center for Cancer Biology, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8824-4015
Sara ZanivanCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-9880-9099
Jan CoolsLaboratory for Molecular Biology of Leukemia, VIB-KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6626-5843
Hans WildiersLaboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8990-7837
Véronique BaudUniversité Paris Cité, NF-kappaB, Différenciation et Cancer, Paris, France.ORCID http://orcid.org/0000-0002-4090-718X
Thomas G P GrünewaldHopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0920-7377
Uri Ben-DavidDepartment of Human Molecular Genetics & Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.ORCID http://orcid.org/0000-0001-7098-2378
Christine DesmedtLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-5223-5579
Ilaria MalanchiThe Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-4867-3311
Sarah-Maria FendtLaboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium. sarah-maria.fendt@kuleuven.be.ORCID http://orcid.org/0000-0001-6018-9296
VIB-KU Leuven Center for Cancer Biology · BEKU Leuven · BECancer Research UK Scotland Institute · GBThe Francis Crick Institute · GBGerman Cancer Research Center · DEScience for Life Laboratory · SETel Aviv University · ILUniversité Paris Cité · FRJiangsu University · CNUniversity of Pardubice · CZ
Funding
Cancer Research UK 14257Cancer Research UK 29800Cancer Research UK FC001112European Research Council 771486European Research Council 773208
Abstract
Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation; however, some nutrients available at distant organs may inherently promote metastatic growth. We find that the lung and liver are lipid-rich environments. Moreover, we observe that pre-metastatic niche formation increases palmitate availability only in the lung, whereas a high-fat diet increases it in both organs. In line with this, targeting palmitate processing inhibits breast cancer-derived lung metastasis formation. Mechanistically, breast cancer cells use palmitate to synthesize acetyl-CoA in a carnitine palmitoyltransferase 1a-dependent manner. Concomitantly, lysine acetyltransferase 2a expression is promoted by palmitate, linking the available acetyl-CoA to the acetylation of the nuclear factor-kappaB subunit p65. Deletion of lysine acetyltransferase 2a or carnitine palmitoyltransferase 1a reduces metastasis formation in lean and high-fat diet mice, and lung and liver metastases from patients with breast cancer show coexpression of both proteins. In conclusion, palmitate-rich environments foster metastases growth by increasing p65 acetylation, resulting in a pro-metastatic nuclear factor-kappaB signaling.
Indexed as
Lysine AcetyltransferasesNF-kappa BAcetylationAcetyl Coenzyme AAnimalsCarnitine O-PalmitoyltransferaseMicePalmitatesAcetyl Coenzyme ACarnitine O-PalmitoyltransferaseLysine AcetyltransferasesNF-kappa BPalmitates
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.