Evidence map›Paper›PMID 36732489›Full record

ArticleSurgical endoscopy2023

Metachronous gastric neoplasm beyond 5 years after endoscopic resection for early gastric cancer.

Eunwoo Lee, Sang Gyun Kim, Bokyung Kim, Jue Lie Kim, Jung Kim, Hyunsoo Chung, Soo-Jeong Cho

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Frontiers in medicine · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Eunwoo LeeDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Daehangno 101, Jongno-Gu, Seoul, 03080, South Korea.
Sang Gyun KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Daehangno 101, Jongno-Gu, Seoul, 03080, South Korea. harley1333@hanmail.net.ORCID 0000-0003-1799-9028
Bokyung KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Daehangno 101, Jongno-Gu, Seoul, 03080, South Korea.
Jue Lie KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Daehangno 101, Jongno-Gu, Seoul, 03080, South Korea.
Jung KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Daehangno 101, Jongno-Gu, Seoul, 03080, South Korea.
Hyunsoo ChungDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Daehangno 101, Jongno-Gu, Seoul, 03080, South Korea.
Soo-Jeong ChoDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Daehangno 101, Jongno-Gu, Seoul, 03080, South Korea.
Seoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe natural course of early gastric cancer (EGC) following endoscopic submucosal dissection (ESD) remains unclear. This study aimed to clarify the long-term clinical outcomes and risk factors of metachronous gastric neoplasm (MGN) 5 years after ESD for EGC.

methodsWe performed a retrospective analysis of patients who underwent ESD for EGC from July 2005 to October 2015 in Seoul National University Hospital. Long-term clinical outcomes and risk factors of MGN after 5 years post-ESD were evaluated.

resultsAmong the 2059 patients who underwent ESD for EGC, 1102 were followed up for > 5 years. MGN developed in 132 patients 5 years after ESD. During the median follow-up period of 85 months, the cumulative incidences of MGN and metachronous gastric cancer were 11.7, 16.9, and 27.0 and 7.6, 10.8, and 18.7% after 5, 7, and 10 years, respectively. In multivariable analysis, male sex (odds ratio 1.770; P = 0.042), severe intestinal metaplasia (odds ratio 1.255; P = 0.000), tumor-positive lateral margin (odds ratio 2.711; P = 0.008), < 5 mm lateral safety margin (odds ratio 1.568; P = 0.050), and synchronous adenoma (odds ratio 2.612; P = 0.001) were positive predictive factors, and successful eradication of Helicobacter pylori (odds ratio 0.514; P = 0.024) was a negative predictive factor for MGN after 5 years post-ESD.

conclusionThe cumulative MGN incidence was high even 5 years post-ESD for EGC. Meticulous long-term endoscopic follow-up is mandatory, especially in male patients with underlying intestinal metaplasia, tumor-positive lateral margins, lateral safety margins of < 5 mm, and synchronous adenomas.

Indexed as

Endoscopic Mucosal ResectionNeoplasms, Second PrimaryStomach NeoplasmsGastric MucosaGastroscopyHumansMaleMetaplasiaRetrospective StudiesTreatment OutcomeEarly gastric cancerEndoscopic resectionEndoscopic submucosal dissectionMetachronous gastric cancerMetachronous gastric neoplasm

Identifiers

PMID36732489
OpenAlexW4318976642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.