ArticleNature plants2023
The F-box protein UFO controls flower development by redirecting the master transcription factor LEAFY to new cis-elements.
Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Post-Translational Control of TaFT1 by WAPO1 Ubiquitination Shapes Spike Architecture and Yield in Wheat.Plant biotechnology journal · 2026Article
- Incomplete functional divergence drives MADS-box gene synergy during floral development in tomato.PLoS biology · 2026Article
- Two LEAFY homologs regulate floral patterning and development without affecting flowering time in kiwifruit.Journal of experimental botany · 2026Article
- Review
- Genomic dissection of Botrytis grey mould resistance in chickpea (Cicer arietinum L.) using QTL-seq approach.Plant cell reports · 2026Article
- Integrating meristem initiation and floral fate control: towardFrontiers in plant science · 2026Review
- Root triterpenoid metabolites drive the assembly and feedback regulation of the rhizosphere microbiome during flowering to senescence inFrontiers in microbiology · 2026Article
- Hyperoside, a flavonoid, inducesScience advances · 2025Article
- Article
- Tomato flowering depends on overlapping functions of AP1/FUL-like genes in reproductive meristem specification.The New phytologist · 2025Article
- The OsbZIP35-COR1-OsTCP19 module modulates cell proliferation to regulate grain length and weight in rice.Science advances · 2025Article
- Spatiotemporal Transcriptomic Atlas Reveals the Regulatory Mechanisms Underlying Early Inflorescence Development and Sex Differentiation in Spinach.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Expression variation of Viola APETALA3 orthologous genes is correlated with chasmogamous and cleistogamous flower development.BMC plant biology · 2025Article
- Genome-wide identification of F-box-LRR gene family and the functional analysis of CsFBXL13 transcription factor in tea plants.Functional & integrative genomics · 2025Article
- Construction of high-density bin genetic map and QTL mapping of fruit aroma in longan (Frontiers in plant science · 2025Article
- Evolution and development of complex floral displays.Development (Cambridge, England) · 2024Review
- Natural alleles of LEAFY and WAPO1 interact to regulate spikelet number per spike in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat.Development (Cambridge, England) · 2024Article
- Mapping quantitative trait loci associated with self-(in)compatibility in goji berries (Lycium barbarum).BMC plant biology · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
In angiosperms, flower development requires the combined action of the transcription factor LEAFY (LFY) and the ubiquitin ligase adaptor F-box protein, UNUSUAL FLORAL ORGANS (UFO), but the molecular mechanism underlying this synergy has remained unknown. Here we show in transient assays and stable transgenic plants that the connection to ubiquitination pathways suggested by the UFO F-box domain is mostly dispensable. On the basis of biochemical and genome-wide studies, we establish that UFO instead acts by forming an active transcriptional complex with LFY at newly discovered regulatory elements. Structural characterization of the LFY-UFO-DNA complex by cryo-electron microscopy further demonstrates that UFO performs this function by directly interacting with both LFY and DNA. Finally, we propose that this complex might have a deep evolutionary origin, largely predating flowering plants. This work reveals a unique mechanism of an F-box protein directly modulating the DNA binding specificity of a master transcription factor.
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